The Emergence of Allosteric Modulators for G Protein-Coupled Receptors

Karen J. Gregory; Celine Valant; John Simms; Patrick M. Sexton; Arthur Christopoulos

doi:10.1002/9780470627327.ch3

The Emergence of Allosteric Modulators for G Protein-Coupled Receptors

Karen J. Gregory^*, Celine Valant, John Simms, Patrick M. Sexton, Arthur Christopoulos

^*Corresponding author for this work

Research output: Chapter in Book/Published conference output › Chapter

Abstract

This chapter contains sections titled:

Introduction

Foundations of Allosteric Receptor Theory

Models for Understanding the Effects of Allosteric Modulators

Types of Allosteric Modulators and Their Properties

Detection and Quantification of Allosteric Interactions

Some Examples of GPCR Allosteric Modulators

Concluding Remarks

References

Original language	English
Title of host publication	GPCR Molecular Pharmacology and Drug Targeting
Subtitle of host publication	Shifting Paradigms and New Directions
Publisher	Wiley
Chapter	3
Pages	61-87
Number of pages	27
ISBN (Print)	9780470307786
DOIs	https://doi.org/10.1002/9780470627327.ch3
Publication status	Published - 15 Jul 2010

Keywords

Allosteric interactions at GPCRs, with profound perturbations in ligand binding and GPCR function
Allosteric modulator emergence - for G protein-coupled receptors
Allosteric theory and allosteric modulators and their properties

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10.1002/9780470627327.ch3

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abstract = "This chapter contains sections titled:IntroductionFoundations of Allosteric Receptor TheoryModels for Understanding the Effects of Allosteric ModulatorsTypes of Allosteric Modulators and Their PropertiesDetection and Quantification of Allosteric InteractionsSome Examples of GPCR Allosteric ModulatorsConcluding RemarksReferences",

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AU - Sexton, Patrick M.

AU - Christopoulos, Arthur

PY - 2010/7/15

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AB - This chapter contains sections titled:IntroductionFoundations of Allosteric Receptor TheoryModels for Understanding the Effects of Allosteric ModulatorsTypes of Allosteric Modulators and Their PropertiesDetection and Quantification of Allosteric InteractionsSome Examples of GPCR Allosteric ModulatorsConcluding RemarksReferences

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PB - Wiley

ER -

The Emergence of Allosteric Modulators for G Protein-Coupled Receptors

Abstract

Keywords

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