The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project

Sara Carucci; Alessandro Zuddas; Angelico Lampis; Kenneth K. C. Man; Carla Balia; Jan Buitelaar; Marina Danckaerts; Ralf W. Dittmann; Federica Donno; Bruno Falissard; Antonella Gagliano; Peter Garas; Alexander Häge; Chris Hollis; Sarah K. Inglis; Kerstin Konrad; Hanna Kovshoff; Elizabeth Liddle; Suzanne McCarthy; Antje Neubert; Peter Nagy; Eric Rosenthal; Edmund J. S. Sonuga-Barke; Ian C. K. Wong; Tobias Banaschewski; David Coghill

doi:10.1177/10870547241226726

The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project

Sara Carucci
, Alessandro Zuddas
, Angelico Lampis
, Kenneth K. C. Man
, Carla Balia
, Jan Buitelaar
, Marina Danckaerts
, Ralf W. Dittmann
, Federica Donno
, Bruno Falissard
, Antonella Gagliano
, Peter Garas
, Alexander Häge
, Chris Hollis
, Sarah K. Inglis
, Kerstin Konrad
, Hanna Kovshoff
, Elizabeth Liddle
, Suzanne McCarthy
, Antje Neubert

Peter Nagy, Eric Rosenthal, Edmund J. S. Sonuga-Barke, Ian C. K. Wong, Tobias Banaschewski, David Coghill

ASL Cagliari, Italy
Anglia Ruskin University Cambridge UK,University College London London UK
Department of Family Medicine, the University of Hong Kong Shenzhen Hospital, The University of Hong Kong, Hong Kong SAR, China.
Karakter Child and Adolescent Psychiatry University Centre, Nijmegen, The Netherlands
University Psychiatric Center KU Leuven, Belgium
Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karis-University Heidelberg, Mannheim, Germany
Department of Electrical and Electronic Engineering, University of Cagliari, 09123 Cagliari, Italy
School of Chemistry and Biosciences, University of Bradford, BD7 1DP, Bradford, United Kingdom; Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay, 92296 Châtenay-Malabry, France
i Department of Biomedical Sciences, University of Messina , Messina , Italy.
Department of Ophthalmology, Semmelweis University, Budapest, Hungary,Faculty of Health Sciences, Semmelweis University, Budapest, Hungary
The University of Nottingham, UK
University of Dundee
RWTH Aachen and Research Centre Jülich, Germany
University of Southampton
University College Cork
Universitätsklinikum Erlangen, Germany
Bethesda Children’s Hospital, Budapest, Hungary
Children’s Neurosciences, Evelina London Children’s Hospital at Guy’s and St Thomas’ National Health Service Foundation Trust, London, United Kingdom,Department of Women and Children’s Health, School of Life Course Sciences, King’s College London, United Kingdom
King's College London
Centre for Social and Early Emotional Development, School of Psychology, Deakin University , Canberra, VIC , Australia; Department of Paediatrics, University of Melbourne , Melbourne, VIC , Australia; Judith Lumley Centre, La Trobe University , Melbourne, VIC , Australia

Research output: Contribution to journal › Article › peer-review

7 Citations (SciVal)

Abstract

Objective: The short-term safety of methylphenidate (MPH) has been widely demonstrated; however the long-term safety is less clear. The aim of this study was to investigate the safety of MPH in relation to pubertal maturation and to explore the monitoring of bone age. Method: Participants from ADDUCE, a two-year observational longitudinal study with three parallel cohorts (MPH group, no-MPH group, and a non-ADHD control group), were compared with respect to Tanner staging. An Italian subsample of medicated-ADHD was further assessed by the monitoring of bone age. Results: The medicated and unmedicated ADHD groups did not differ in Tanner stages indicating no higher risk of sexual maturational delay in the MPH-treated patients. The medicated subsample monitored for bone age showed a slight acceleration of the bone maturation after 24 months, however their predicted adult height remained stable. Conclusion: Our results do not suggest safety concerns on long-term treatment with MPH in relation to pubertal maturation and growth.

Original language	English
Pages (from-to)	722-739
Number of pages	18
Journal	Journal of Attention Disorders
Volume	28
Issue number	5
Early online date	17 Feb 2024
DOIs	https://doi.org/10.1177/10870547241226726
Publication status	Published - 1 Mar 2024

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Carucci, S., Zuddas, A., Lampis, A., Man, K. K. C., Balia, C., Buitelaar, J., Danckaerts, M., Dittmann, R. W., Donno, F., Falissard, B., Gagliano, A., Garas, P., Häge, A., Hollis, C., Inglis, S. K., Konrad, K., Kovshoff, H., Liddle, E., McCarthy, S., ... Coghill, D. (2024). The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project. Journal of Attention Disorders, 28(5), 722-739. https://doi.org/10.1177/10870547241226726

@article{dfdcea250db441fc91534cb3a693e635,

title = "The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project",

abstract = "Objective: The short-term safety of methylphenidate (MPH) has been widely demonstrated; however the long-term safety is less clear. The aim of this study was to investigate the safety of MPH in relation to pubertal maturation and to explore the monitoring of bone age. Method: Participants from ADDUCE, a two-year observational longitudinal study with three parallel cohorts (MPH group, no-MPH group, and a non-ADHD control group), were compared with respect to Tanner staging. An Italian subsample of medicated-ADHD was further assessed by the monitoring of bone age. Results: The medicated and unmedicated ADHD groups did not differ in Tanner stages indicating no higher risk of sexual maturational delay in the MPH-treated patients. The medicated subsample monitored for bone age showed a slight acceleration of the bone maturation after 24 months, however their predicted adult height remained stable. Conclusion: Our results do not suggest safety concerns on long-term treatment with MPH in relation to pubertal maturation and growth.",

author = "Sara Carucci and Alessandro Zuddas and Angelico Lampis and Man, \{Kenneth K. C.\} and Carla Balia and Jan Buitelaar and Marina Danckaerts and Dittmann, \{Ralf W.\} and Federica Donno and Bruno Falissard and Antonella Gagliano and Peter Garas and Alexander H{\"a}ge and Chris Hollis and Inglis, \{Sarah K.\} and Kerstin Konrad and Hanna Kovshoff and Elizabeth Liddle and Suzanne McCarthy and Antje Neubert and Peter Nagy and Eric Rosenthal and Sonuga-Barke, \{Edmund J. S.\} and Wong, \{Ian C. K.\} and Tobias Banaschewski and David Coghill",

year = "2024",

month = mar,

day = "1",

doi = "10.1177/10870547241226726",

language = "English",

volume = "28",

pages = "722--739",

journal = "Journal of Attention Disorders",

issn = "1087-0547",

publisher = "SAGE",

number = "5",

}

Carucci, S, Zuddas, A, Lampis, A, Man, KKC, Balia, C, Buitelaar, J, Danckaerts, M, Dittmann, RW, Donno, F, Falissard, B, Gagliano, A, Garas, P, Häge, A, Hollis, C, Inglis, SK, Konrad, K, Kovshoff, H, Liddle, E, McCarthy, S, Neubert, A, Nagy, P, Rosenthal, E, Sonuga-Barke, EJS, Wong, ICK, Banaschewski, T & Coghill, D 2024, 'The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project', Journal of Attention Disorders, vol. 28, no. 5, pp. 722-739. https://doi.org/10.1177/10870547241226726

The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project. / Carucci, Sara; Zuddas, Alessandro; Lampis, Angelico et al.
In: Journal of Attention Disorders, Vol. 28, No. 5, 01.03.2024, p. 722-739.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project

AU - Carucci, Sara

AU - Zuddas, Alessandro

AU - Lampis, Angelico

AU - Man, Kenneth K. C.

AU - Balia, Carla

AU - Buitelaar, Jan

AU - Danckaerts, Marina

AU - Dittmann, Ralf W.

AU - Donno, Federica

AU - Falissard, Bruno

AU - Gagliano, Antonella

AU - Garas, Peter

AU - Häge, Alexander

AU - Hollis, Chris

AU - Inglis, Sarah K.

AU - Konrad, Kerstin

AU - Kovshoff, Hanna

AU - Liddle, Elizabeth

AU - McCarthy, Suzanne

AU - Neubert, Antje

AU - Nagy, Peter

AU - Rosenthal, Eric

AU - Sonuga-Barke, Edmund J. S.

AU - Wong, Ian C. K.

AU - Banaschewski, Tobias

AU - Coghill, David

PY - 2024/3/1

Y1 - 2024/3/1

N2 - Objective: The short-term safety of methylphenidate (MPH) has been widely demonstrated; however the long-term safety is less clear. The aim of this study was to investigate the safety of MPH in relation to pubertal maturation and to explore the monitoring of bone age. Method: Participants from ADDUCE, a two-year observational longitudinal study with three parallel cohorts (MPH group, no-MPH group, and a non-ADHD control group), were compared with respect to Tanner staging. An Italian subsample of medicated-ADHD was further assessed by the monitoring of bone age. Results: The medicated and unmedicated ADHD groups did not differ in Tanner stages indicating no higher risk of sexual maturational delay in the MPH-treated patients. The medicated subsample monitored for bone age showed a slight acceleration of the bone maturation after 24 months, however their predicted adult height remained stable. Conclusion: Our results do not suggest safety concerns on long-term treatment with MPH in relation to pubertal maturation and growth.

AB - Objective: The short-term safety of methylphenidate (MPH) has been widely demonstrated; however the long-term safety is less clear. The aim of this study was to investigate the safety of MPH in relation to pubertal maturation and to explore the monitoring of bone age. Method: Participants from ADDUCE, a two-year observational longitudinal study with three parallel cohorts (MPH group, no-MPH group, and a non-ADHD control group), were compared with respect to Tanner staging. An Italian subsample of medicated-ADHD was further assessed by the monitoring of bone age. Results: The medicated and unmedicated ADHD groups did not differ in Tanner stages indicating no higher risk of sexual maturational delay in the MPH-treated patients. The medicated subsample monitored for bone age showed a slight acceleration of the bone maturation after 24 months, however their predicted adult height remained stable. Conclusion: Our results do not suggest safety concerns on long-term treatment with MPH in relation to pubertal maturation and growth.

UR - https://journals.sagepub.com/doi/10.1177/10870547241226726

U2 - 10.1177/10870547241226726

DO - 10.1177/10870547241226726

M3 - Article

SN - 1087-0547

VL - 28

SP - 722

EP - 739

JO - Journal of Attention Disorders

JF - Journal of Attention Disorders

IS - 5

ER -

The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project

Abstract

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