The impact of paediatric epilepsy and co-occurring neurodevelopmental disorders on functional brain networks in wake and sleep

Leandro Junges; Daniel Galvis; Alice Winsor; Grace Treadwell; Caroline Richards; Stefano Seri; Samuel Johnson; John R. Terry; Andrew P. Bagshaw

doi:10.1371/journal.pone.0309243

The impact of paediatric epilepsy and co-occurring neurodevelopmental disorders on functional brain networks in wake and sleep

Leandro Junges^*, Daniel Galvis, Alice Winsor, Grace Treadwell, Caroline Richards, Stefano Seri, Samuel Johnson, John R. Terry, Andrew P. Bagshaw

^*Corresponding author for this work

School of Psychology

Research output: Contribution to journal › Article › peer-review

Abstract

Epilepsy is one of the most common neurological disorders in children. Diagnosing epilepsy in children can be very challenging, especially as it often coexists with neurodevelopmental conditions like autism and ADHD. Functional brain networks obtained from neuroimaging and electrophysiological data in wakefulness and sleep have been shown to contain signatures of neurological disorders, and can potentially support the diagnosis and management of co-occurring neurodevelopmental conditions. In this work, we use electroencephalography (EEG) recordings from children, in restful wakefulness and sleep, to extract functional connectivity networks in different frequency bands. We explore the relationship of these networks with epilepsy diagnosis and with measures of neurodevelopmental traits, obtained from questionnaires used as screening tools for autism and ADHD. We explore differences in network markers between children with and without epilepsy in wake and sleep, and quantify the correlation between such markers and measures of neurodevelopmental traits. Our findings highlight the importance of considering the interplay between epilepsy and neurodevelopmental traits when exploring network markers of epilepsy.

Original language	English
Article number	e0309243
Number of pages	14
Journal	PLoS ONE
Volume	19
Issue number	8
Early online date	26 Aug 2024
DOIs	https://doi.org/10.1371/journal.pone.0309243
Publication status	Published - 26 Aug 2024

Bibliographical note

Copyright © 2024 Junges et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Data Access Statement

Data cannot be shared publicly because participants did not give their consent to open sharing of their data and this was not covered in the ethical approval of this study. Data contain potentially sensitive patient information (restrictions imposed by North West - Preston Research Ethics Committee). For data availability please contact the North West - Preston Research Ethics Committee - Ref. 19/NW/0337 ([email protected]).

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Copyright © 2024 Junges et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Final published version, 1.57 MBLicence: CC BY 4.0

Cite this

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title = "The impact of paediatric epilepsy and co-occurring neurodevelopmental disorders on functional brain networks in wake and sleep",

abstract = "Epilepsy is one of the most common neurological disorders in children. Diagnosing epilepsy in children can be very challenging, especially as it often coexists with neurodevelopmental conditions like autism and ADHD. Functional brain networks obtained from neuroimaging and electrophysiological data in wakefulness and sleep have been shown to contain signatures of neurological disorders, and can potentially support the diagnosis and management of co-occurring neurodevelopmental conditions. In this work, we use electroencephalography (EEG) recordings from children, in restful wakefulness and sleep, to extract functional connectivity networks in different frequency bands. We explore the relationship of these networks with epilepsy diagnosis and with measures of neurodevelopmental traits, obtained from questionnaires used as screening tools for autism and ADHD. We explore differences in network markers between children with and without epilepsy in wake and sleep, and quantify the correlation between such markers and measures of neurodevelopmental traits. Our findings highlight the importance of considering the interplay between epilepsy and neurodevelopmental traits when exploring network markers of epilepsy.",

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AU - Winsor, Alice

AU - Treadwell, Grace

AU - Richards, Caroline

AU - Seri, Stefano

AU - Johnson, Samuel

AU - Terry, John R.

AU - Bagshaw, Andrew P.

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The impact of paediatric epilepsy and co-occurring neurodevelopmental disorders on functional brain networks in wake and sleep

Abstract

Bibliographical note

Data Access Statement

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