The influence of serum, glucose and oxygen on intervertebral disc cell growth in vitro: implications for degenerative disc disease

William E.B. Johnson, Simon Stephan, Sally Roberts

Research output: Contribution to journalArticle

Abstract

The avascular nature of the human intervertebral disc (IVD) is thought to play a major role in disc pathophysiology by limiting nutrient supply to resident IVD cells. In the human IVD, the central IVD cells at maturity are normally chondrocytic in phenotype. However, abnormal cell phenotypes have been associated with degenerative disc diseases, including cell proliferation and cluster formation, cell death, stellate morphologies, and cell senescence. Therefore, we have examined the relative influence of possible blood-borne factors on the growth characteristics of IVD cells in vitro.
Original languageEnglish
Article numberR46
Pages (from-to)R46
JournalArthritis Research and Therapy
Volume10
Issue number2
DOIs
Publication statusPublished - 23 Apr 2008

Bibliographical note

© 2008 Johnson et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords

  • animals
  • cattle
  • cell aging
  • cell proliferation
  • cultured cells
  • collagen type I
  • collagen type II
  • glucose
  • intervertebral disc
  • oxygen
  • serum
  • beta-galactosidase

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