The Laser Technologies of Targeted Opening of Blood-Brain Barrier for Drug Brain Delivery

O.v. Semyachkina-glushkovskaya; E.u. Rafailov; S.g. Sokolovsky; E.g. Borisova; Vanya Mantareva; Ivan Angelov; Alexander Shirokov; Nikita Navolokin; N.a. Shushunova; A.p. Khorovodov; A.v. Terskov; A.a. Bodrova; M.v. Ulanova; Esmat Shrif; V.v. Tuchin; J. Kurths

doi:10.1109/LO.2018.8435846

The Laser Technologies of Targeted Opening of Blood-Brain Barrier for Drug Brain Delivery

O.v. Semyachkina-glushkovskaya, E.u. Rafailov, S.g. Sokolovsky, E.g. Borisova, Vanya Mantareva, Ivan Angelov, Alexander Shirokov, Nikita Navolokin, N.a. Shushunova, A.p. Khorovodov, A.v. Terskov, A.a. Bodrova, M.v. Ulanova, Esmat Shrif, V.v. Tuchin, J. Kurths

Aston Institute of Photonic Technologies (AiPT)

Research output: Chapter in Book/Published conference output › Conference publication

Abstract

Here we show the photodynamic treatment (PDT) causes significant increase in the permeability of the blood-brain barrier (BBB) in healthy mice. Using different doses of laser (635 nm, 10-40 J/cm 2 ) and photosensitizer (5-aminole-vulinic acid – 5-ALA, 20 and 80 mg/kg, i.v.), we found the optimal PDT for the reversible opening of BBB that is 15 J/cm 2 and 5-ALA, 20 mg/kg, when the brain tissues recover 3 days later. Further increase in the laser or 5-ALA doses has not amplifying effect on the BBB but associated with severe damages of brain tissues. These results can be good informative platform for the further studies of new strategies in brain drug delivery and for the better understanding of mechanisms underlying cerebrovascular effects of PD-related fluorescence guided resection of brain tumor.

Original language	English
Title of host publication	2018 International Conference Laser Optics (ICLO)
Publisher	IEEE
Pages	501-501
ISBN (Electronic)	978-1-5386-3612-1
ISBN (Print)	978-1-5386-3611-4
DOIs	https://doi.org/10.1109/LO.2018.8435846
Publication status	Published - 16 Aug 2018
Event	2018 International Conference Laser Optics (ICLO) - Saint Petersburg, Russia, Saint Petersburg, Russian Federation Duration: 4 Jun 2018 → 8 Jun 2018

Conference

Conference	2018 International Conference Laser Optics (ICLO)
Country/Territory	Russian Federation
City	Saint Petersburg
Period	4/06/18 → 8/06/18

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10.1109/LO.2018.8435846

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Semyachkina-glushkovskaya, O. V., Rafailov, E. U., Sokolovsky, S. G., Borisova, E. G., Mantareva, V., Angelov, I., Shirokov, A., Navolokin, N., Shushunova, N. A., Khorovodov, A. P., Terskov, A. V., Bodrova, A. A., Ulanova, M. V., Shrif, E., Tuchin, V. V., & Kurths, J. (2018). The Laser Technologies of Targeted Opening of Blood-Brain Barrier for Drug Brain Delivery. In 2018 International Conference Laser Optics (ICLO) (pp. 501-501). IEEE. https://doi.org/10.1109/LO.2018.8435846

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title = "The Laser Technologies of Targeted Opening of Blood-Brain Barrier for Drug Brain Delivery",

abstract = "Here we show the photodynamic treatment (PDT) causes significant increase in the permeability of the blood-brain barrier (BBB) in healthy mice. Using different doses of laser (635 nm, 10-40 J/cm 2 ) and photosensitizer (5-aminole-vulinic acid – 5-ALA, 20 and 80 mg/kg, i.v.), we found the optimal PDT for the reversible opening of BBB that is 15 J/cm 2 and 5-ALA, 20 mg/kg, when the brain tissues recover 3 days later. Further increase in the laser or 5-ALA doses has not amplifying effect on the BBB but associated with severe damages of brain tissues. These results can be good informative platform for the further studies of new strategies in brain drug delivery and for the better understanding of mechanisms underlying cerebrovascular effects of PD-related fluorescence guided resection of brain tumor.",

author = "O.v. Semyachkina-glushkovskaya and E.u. Rafailov and S.g. Sokolovsky and E.g. Borisova and Vanya Mantareva and Ivan Angelov and Alexander Shirokov and Nikita Navolokin and N.a. Shushunova and A.p. Khorovodov and A.v. Terskov and A.a. Bodrova and M.v. Ulanova and Esmat Shrif and V.v. Tuchin and J. Kurths",

year = "2018",

month = aug,

day = "16",

doi = "10.1109/LO.2018.8435846",

language = "English",

isbn = "978-1-5386-3611-4",

pages = "501--501",

booktitle = "2018 International Conference Laser Optics (ICLO)",

publisher = "IEEE",

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note = "2018 International Conference Laser Optics (ICLO) ; Conference date: 04-06-2018 Through 08-06-2018",

}

Semyachkina-glushkovskaya, OV, Rafailov, EU, Sokolovsky, SG, Borisova, EG, Mantareva, V, Angelov, I, Shirokov, A, Navolokin, N, Shushunova, NA, Khorovodov, AP, Terskov, AV, Bodrova, AA, Ulanova, MV, Shrif, E, Tuchin, VV & Kurths, J 2018, The Laser Technologies of Targeted Opening of Blood-Brain Barrier for Drug Brain Delivery. in 2018 International Conference Laser Optics (ICLO). IEEE, pp. 501-501, 2018 International Conference Laser Optics (ICLO), Saint Petersburg, Russian Federation, 4/06/18. https://doi.org/10.1109/LO.2018.8435846

TY - GEN

T1 - The Laser Technologies of Targeted Opening of Blood-Brain Barrier for Drug Brain Delivery

AU - Semyachkina-glushkovskaya, O.v.

AU - Rafailov, E.u.

AU - Sokolovsky, S.g.

AU - Borisova, E.g.

AU - Mantareva, Vanya

AU - Angelov, Ivan

AU - Shirokov, Alexander

AU - Navolokin, Nikita

AU - Shushunova, N.a.

AU - Khorovodov, A.p.

AU - Terskov, A.v.

AU - Bodrova, A.a.

AU - Ulanova, M.v.

AU - Shrif, Esmat

AU - Tuchin, V.v.

AU - Kurths, J.

PY - 2018/8/16

Y1 - 2018/8/16

N2 - Here we show the photodynamic treatment (PDT) causes significant increase in the permeability of the blood-brain barrier (BBB) in healthy mice. Using different doses of laser (635 nm, 10-40 J/cm 2 ) and photosensitizer (5-aminole-vulinic acid – 5-ALA, 20 and 80 mg/kg, i.v.), we found the optimal PDT for the reversible opening of BBB that is 15 J/cm 2 and 5-ALA, 20 mg/kg, when the brain tissues recover 3 days later. Further increase in the laser or 5-ALA doses has not amplifying effect on the BBB but associated with severe damages of brain tissues. These results can be good informative platform for the further studies of new strategies in brain drug delivery and for the better understanding of mechanisms underlying cerebrovascular effects of PD-related fluorescence guided resection of brain tumor.

AB - Here we show the photodynamic treatment (PDT) causes significant increase in the permeability of the blood-brain barrier (BBB) in healthy mice. Using different doses of laser (635 nm, 10-40 J/cm 2 ) and photosensitizer (5-aminole-vulinic acid – 5-ALA, 20 and 80 mg/kg, i.v.), we found the optimal PDT for the reversible opening of BBB that is 15 J/cm 2 and 5-ALA, 20 mg/kg, when the brain tissues recover 3 days later. Further increase in the laser or 5-ALA doses has not amplifying effect on the BBB but associated with severe damages of brain tissues. These results can be good informative platform for the further studies of new strategies in brain drug delivery and for the better understanding of mechanisms underlying cerebrovascular effects of PD-related fluorescence guided resection of brain tumor.

UR - https://ieeexplore.ieee.org/document/8435846/

U2 - 10.1109/LO.2018.8435846

DO - 10.1109/LO.2018.8435846

M3 - Conference publication

SN - 978-1-5386-3611-4

SP - 501

EP - 501

BT - 2018 International Conference Laser Optics (ICLO)

PB - IEEE

T2 - 2018 International Conference Laser Optics (ICLO)

Y2 - 4 June 2018 through 8 June 2018

ER -

The Laser Technologies of Targeted Opening of Blood-Brain Barrier for Drug Brain Delivery

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