The levels of neopterin, biopterin and the neopterin/biopterin ratio in urine from control subjects and patients with Alzheimer’s disease and Down’s syndrome

J.A. Blair, S.J. Winsper, R.J. Cattell, Richard A. Armstrong

Research output: Contribution to journalArticle

Abstract

The levels of neopterin, biopterin and the neopterin/biopterin ratio (N/B) were measured in urine samples taken from normal young and elderly control subjects, exceptionally healthy elderly control subjects classified according to the ‘Senieur’ protocol and patients with Down’s syndrome (DS) or Alzheimer’s disease (AD). The N/B ratio was approximately unity in control groups with the exception of the normal elderly controls. The levels of neopterin and biopterin declined with age in the exceptionally healthy ‘Senieur’ control group. The N/B ratio was elevated in young and old DS patients as a result of the significant increase in neopterin. Neopterin levels were significantly elevated in AD patients compared with the healthy elderly controls, but this did not result in a significant increase in the N/B ratio in these patients. The N/B ratio increased with age in AD patients as a result of a decline in biopterin. These results suggested that there is a cellular immune reponse in DS and AD patients which in DS, may precede the formation of beta-amyloid deposits in the brain. In addition, there may be a deficiency in tetrahydrobiopterin biosynthesis in AD which becomes more marked with age.
Original languageEnglish
Pages (from-to)185-189
Number of pages5
JournalPteridines
Volume6
Issue number4
DOIs
Publication statusPublished - 1995

Fingerprint

Biopterin
Neopterin
Down Syndrome
Alzheimer Disease
Urine
Control Groups
Phenylketonurias
Biosynthesis
Amyloid Plaques
Amyloid
Brain
Healthy Volunteers
Deposits

Keywords

  • Neopterin
  • Biopterin
  • Neopterin/Biopterin ratio
  • control subjects
  • Alzheimer’s disease
  • Down’s syndrome

Cite this

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abstract = "The levels of neopterin, biopterin and the neopterin/biopterin ratio (N/B) were measured in urine samples taken from normal young and elderly control subjects, exceptionally healthy elderly control subjects classified according to the ‘Senieur’ protocol and patients with Down’s syndrome (DS) or Alzheimer’s disease (AD). The N/B ratio was approximately unity in control groups with the exception of the normal elderly controls. The levels of neopterin and biopterin declined with age in the exceptionally healthy ‘Senieur’ control group. The N/B ratio was elevated in young and old DS patients as a result of the significant increase in neopterin. Neopterin levels were significantly elevated in AD patients compared with the healthy elderly controls, but this did not result in a significant increase in the N/B ratio in these patients. The N/B ratio increased with age in AD patients as a result of a decline in biopterin. These results suggested that there is a cellular immune reponse in DS and AD patients which in DS, may precede the formation of beta-amyloid deposits in the brain. In addition, there may be a deficiency in tetrahydrobiopterin biosynthesis in AD which becomes more marked with age.",
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The levels of neopterin, biopterin and the neopterin/biopterin ratio in urine from control subjects and patients with Alzheimer’s disease and Down’s syndrome. / Blair, J.A.; Winsper, S.J.; Cattell, R.J.; Armstrong, Richard A.

In: Pteridines, Vol. 6, No. 4, 1995, p. 185-189.

Research output: Contribution to journalArticle

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