The light-oxygen effect in biological cells enhanced by highly localized surface plasmon-polaritons

Anna Khokhlova*, Igor Zolotovskii, Sergei Sokolovski, Yury Saenko, Edik Rafailov, Dmitrii Stoliarov, Evgenia Pogodina, Vyacheslav Svetukhin, Vladimir Sibirny, Andrei Fotiadi

*Corresponding author for this work

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Abstract

Here at the first time we suggested that the surface plasmon-polariton phenomenon which it is well described in metallic nanostructures could also be used for explanation of the unexpectedly strong oxidative effects of the low-intensity laser irradiation in living matters (cells, tissues, organism). We demonstrated that the narrow-band laser emitting at 1265 nm could generate significant amount of the reactive oxygen species (ROS) in both HCT116 and CHO-K1 cell cultures. Such cellular ROS effects could be explained through the generation of highly localized plasmon-polaritons on the surface of mitochondrial crista. Our experimental conditions, the low-intensity irradiation, the narrow spectrum band (<4 nm) of the laser and comparably small size bio-structures (~10 μm) were shown to be sufficient for the plasmon-polariton generation and strong laser field confinement enabling the oxidative stress observed.

Original languageEnglish
Article number18435
JournalScientific Reports
Volume9
Issue number1
DOIs
Publication statusPublished - 5 Dec 2019

Bibliographical note

© The Author(s) 2019. Open Access - This article is licensed under a Creative Commons Attribution 4.0 International
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Funding: Russian Foundation for Basic Research (RFBR) (#18-29-19101 (I.Z., D.S.)). Russian Science Foundation (RSF) (#18-12-00457 (A.F., I.Z., D.S.). EU H2020 FET research and innovation program MESO-BRAIN (#713140 (E.R., S.S.)). Ministry of Science and Higher Education of the Russian Federation through the assignment of 2019 year for Scientific-Manufacturing Complex “Technological Centre”.Ministry of Education and Science of Russian Federation (Grant № 12.1223.2017/AP to S.S. and E.R.).

Keywords

  • Biological physics
  • Biophotonics
  • Biophysics
  • Lasers, LEDs and light sources
  • Micro-optics

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  • Research Output

    Author Correction: The light-oxygen effect in biological cells enhanced by highly localized surface plasmon-polaritons (Scientific Reports, (2019), 9, 1, (18435), 10.1038/s41598-019-54905-5)

    Khokhlova, A., Zolotovskii, I., Sokolovski, S., Saenko, Y., Rafailov, E., Stoliarov, D., Pogodina, E., Svetukhin, V., Sibirny, V. & Fotiadi, A., 22 Jan 2020, In : Scientific Reports. 10, 1, 1269.

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    Khokhlova, A., Zolotovskii, I., Sokolovski, S., Saenko, Y., Rafailov, E., Stoliarov, D., Pogodina, E., Svetukhin, V., Sibirny, V., & Fotiadi, A. (2019). The light-oxygen effect in biological cells enhanced by highly localized surface plasmon-polaritons. Scientific Reports, 9(1), [18435]. https://doi.org/10.1038/s41598-019-54905-5