The light-oxygen effect in biological cells enhanced by highly localized surface plasmon-polaritons

Anna Khokhlova; Igor Zolotovskii; Sergei Sokolovski; Yury Saenko; Edik Rafailov; Dmitrii Stoliarov; Evgenia Pogodina; Vyacheslav Svetukhin; Vladimir Sibirny; Andrei Fotiadi

doi:10.1038/s41598-019-54905-5

The light-oxygen effect in biological cells enhanced by highly localized surface plasmon-polaritons

Anna Khokhlova^*, Igor Zolotovskii, Sergei Sokolovski, Yury Saenko, Edik Rafailov, Dmitrii Stoliarov, Evgenia Pogodina, Vyacheslav Svetukhin, Vladimir Sibirny, Andrei Fotiadi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Here at the first time we suggested that the surface plasmon-polariton phenomenon which it is well described in metallic nanostructures could also be used for explanation of the unexpectedly strong oxidative effects of the low-intensity laser irradiation in living matters (cells, tissues, organism). We demonstrated that the narrow-band laser emitting at 1265 nm could generate significant amount of the reactive oxygen species (ROS) in both HCT116 and CHO-K1 cell cultures. Such cellular ROS effects could be explained through the generation of highly localized plasmon-polaritons on the surface of mitochondrial crista. Our experimental conditions, the low-intensity irradiation, the narrow spectrum band (<4 nm) of the laser and comparably small size bio-structures (~10 μm) were shown to be sufficient for the plasmon-polariton generation and strong laser field confinement enabling the oxidative stress observed.

Original language	English
Article number	18435
Journal	Scientific Reports
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41598-019-54905-5
Publication status	Published - 5 Dec 2019

Bibliographical note

© The Author(s) 2019. Open Access - This article is licensed under a Creative Commons Attribution 4.0 International
License, which permits use, sharing, adaptation, distribution and reproduction in any medium or
format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative
Commons license, and indicate if changes were made. The images or other third party material in this
article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the
material. If material is not included in the article’s Creative Commons license and your intended use is not permitted
by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the
copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Funding: Russian Foundation for Basic Research (RFBR) (#18-29-19101 (I.Z., D.S.)). Russian Science Foundation (RSF) (#18-12-00457 (A.F., I.Z., D.S.). EU H2020 FET research and innovation program MESO-BRAIN (#713140 (E.R., S.S.)). Ministry of Science and Higher Education of the Russian Federation through the assignment of 2019 year for Scientific-Manufacturing Complex “Technological Centre”.Ministry of Education and Science of Russian Federation (Grant № 12.1223.2017/AP to S.S. and E.R.).

Keywords

Biological physics
Biophotonics
Biophysics
Lasers, LEDs and light sources
Micro-optics

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10.1038/s41598-019-54905-5Licence: CC BY 3.0

The light-oxygen effect in biological cells
© The Author(s) 2019. Open Access - This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Final published version, 2.4 MBLicence: CC BY 3.0

Cite this

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abstract = "Here at the first time we suggested that the surface plasmon-polariton phenomenon which it is well described in metallic nanostructures could also be used for explanation of the unexpectedly strong oxidative effects of the low-intensity laser irradiation in living matters (cells, tissues, organism). We demonstrated that the narrow-band laser emitting at 1265 nm could generate significant amount of the reactive oxygen species (ROS) in both HCT116 and CHO-K1 cell cultures. Such cellular ROS effects could be explained through the generation of highly localized plasmon-polaritons on the surface of mitochondrial crista. Our experimental conditions, the low-intensity irradiation, the narrow spectrum band (<4 nm) of the laser and comparably small size bio-structures (~10 μm) were shown to be sufficient for the plasmon-polariton generation and strong laser field confinement enabling the oxidative stress observed.",

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AU - Stoliarov, Dmitrii

AU - Pogodina, Evgenia

AU - Svetukhin, Vyacheslav

AU - Sibirny, Vladimir

AU - Fotiadi, Andrei

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The light-oxygen effect in biological cells enhanced by highly localized surface plasmon-polaritons

Abstract

Bibliographical note

Keywords

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Author Correction: The light-oxygen effect in biological cells enhanced by highly localized surface plasmon-polaritons (Scientific Reports, (2019), 9, 1, (18435), 10.1038/s41598-019-54905-5)

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