The long-term effects of the periconceptional period on embryo epigenetic profile and phenotype; The paternal role and his contribution, and how males can affect offspring’s phenotype/epigenetic profile

Emma S. Lucas, Adam J. Watkins*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The number of adults afflicted with heart disease, obesity and diabetes, central components of metabolic disorder, has grown rapidly in recent decades, affecting up to one quarter of the world’s population. Typically, these diseases are attributed to lifestyle factors such as poor diet, lack of exercise and smoking. However, studies have now identified strong associations between patterns of growth during foetal and neonatal life and an increase predisposition towards developing heart disease, obesity and diabetes in adult life. While the connection between a mother’s diet and the long-term health of her offspring has been studied in great detail, our understanding of whether offspring health might be affected by a father’s diet remains limited. Greater insight into the impact that paternal nutrition has on sperm quality, epigenetic status and potential offspring programming mechanisms is needed to redress this parental-programming knowledge imbalance. Disturbances in paternal reproductive epigenetic status represents one key mechanism linking paternal diet with the programing of offspring development and adult health, as many enzymatic processes involved in epigenetic regulation use metabolic intermediates to modify DNA and histones. Here, poor paternal nutrition could result in perturbed sperm and testicular epigenetic status, impacting on post-fertilisation gene transcriptional regulation and protein expression in offspring tissues, resulting in increased incidences of metabolic disorder in adult life.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages137-154
Number of pages18
Volume1014
DOIs
Publication statusPublished - 2017

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1014
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • DNA
  • Histones
  • Metabolic syndrome
  • Paternal nutrition
  • Reproductive fitness

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    Lucas, E. S., & Watkins, A. J. (2017). The long-term effects of the periconceptional period on embryo epigenetic profile and phenotype; The paternal role and his contribution, and how males can affect offspring’s phenotype/epigenetic profile. In Advances in Experimental Medicine and Biology (Vol. 1014, pp. 137-154). (Advances in Experimental Medicine and Biology; Vol. 1014). Springer. https://doi.org/10.1007/978-3-319-62414-3_8