The MacDQoL individualized measure of the impact of macular degeneration on quality of life: reliability and responsiveness

Jan Mitchell, James Wolffsohn, Alison Woodcock, Stephen J. Anderson, Timothy Ffytche, Martin Rubinstein, Winfried Amoaku, Clare Bradley

Research output: Contribution to journalArticle

Abstract

PURPOSE: To investigate the MacDQoL test-retest reliability and sensitivity to change in vision over a period of one year in a sample of patients with age-related macular degeneration (AMD). DESIGN: A prospective, observational study. METHOD: Patients with AMD from an ophthalmologist's list (n = 135) completed the MacDQoL questionnaire by telephone interview and underwent a vision assessment on two occasions, one year apart. RESULTS: Among participants whose vision was stable over one year (n = 87), MacDQoL scores at baseline and follow-up were highly correlated (r = 0.95; P < .0001). Twelve of the 22 scale items had intraclass correlations of >.80; only two were correlated <.7. There was no difference between baseline and follow-up scores (P = .85), indicating excellent test-retest reliability. Poorer quality of life (QoL) at follow-up, measured by the MacDQoL present QoL overview item, was associated with deterioration in both the better eye and binocular distance visual acuity [VA] (r = 0.29; P = .001, r = 0.21; P = .016, respectively; n = 135). There was a positive correlation between deterioration in the Mac. DQoL average weighted impact score and deterioration in both binocular near VA and reading speed (r = 0.20; P = .019, r = 0.18; P = .041, respectively; n = 135). CONCLUSION: The MacDQoL has excellent test-retest reliability. Its sensitivity to change in vision status was demonstrated in correlational analyses. The measure indicates that the negative impact of AMD on QoL increases with increasing severity of visual impairment.
Original languageEnglish
Pages (from-to)447-454
Number of pages8
JournalAmerican Journal of Ophthalmology
Volume146
Issue number3
DOIs
Publication statusPublished - Sep 2008

Fingerprint

Macular Degeneration
Quality of Life
Reproducibility of Results
Visual Acuity
Vision Disorders
Observational Studies
Reading
Prospective Studies
Interviews

Keywords

  • MacDQoL test-retest
  • change in vision
  • age-related macular degeneration
  • visual impairment

Cite this

Mitchell, Jan ; Wolffsohn, James ; Woodcock, Alison ; Anderson, Stephen J. ; Ffytche, Timothy ; Rubinstein, Martin ; Amoaku, Winfried ; Bradley, Clare. / The MacDQoL individualized measure of the impact of macular degeneration on quality of life: reliability and responsiveness. In: American Journal of Ophthalmology. 2008 ; Vol. 146, No. 3. pp. 447-454.
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The MacDQoL individualized measure of the impact of macular degeneration on quality of life: reliability and responsiveness. / Mitchell, Jan; Wolffsohn, James; Woodcock, Alison; Anderson, Stephen J.; Ffytche, Timothy; Rubinstein, Martin; Amoaku, Winfried; Bradley, Clare.

In: American Journal of Ophthalmology, Vol. 146, No. 3, 09.2008, p. 447-454.

Research output: Contribution to journalArticle

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AU - Wolffsohn, James

AU - Woodcock, Alison

AU - Anderson, Stephen J.

AU - Ffytche, Timothy

AU - Rubinstein, Martin

AU - Amoaku, Winfried

AU - Bradley, Clare

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N2 - PURPOSE: To investigate the MacDQoL test-retest reliability and sensitivity to change in vision over a period of one year in a sample of patients with age-related macular degeneration (AMD). DESIGN: A prospective, observational study. METHOD: Patients with AMD from an ophthalmologist's list (n = 135) completed the MacDQoL questionnaire by telephone interview and underwent a vision assessment on two occasions, one year apart. RESULTS: Among participants whose vision was stable over one year (n = 87), MacDQoL scores at baseline and follow-up were highly correlated (r = 0.95; P < .0001). Twelve of the 22 scale items had intraclass correlations of >.80; only two were correlated <.7. There was no difference between baseline and follow-up scores (P = .85), indicating excellent test-retest reliability. Poorer quality of life (QoL) at follow-up, measured by the MacDQoL present QoL overview item, was associated with deterioration in both the better eye and binocular distance visual acuity [VA] (r = 0.29; P = .001, r = 0.21; P = .016, respectively; n = 135). There was a positive correlation between deterioration in the Mac. DQoL average weighted impact score and deterioration in both binocular near VA and reading speed (r = 0.20; P = .019, r = 0.18; P = .041, respectively; n = 135). CONCLUSION: The MacDQoL has excellent test-retest reliability. Its sensitivity to change in vision status was demonstrated in correlational analyses. The measure indicates that the negative impact of AMD on QoL increases with increasing severity of visual impairment.

AB - PURPOSE: To investigate the MacDQoL test-retest reliability and sensitivity to change in vision over a period of one year in a sample of patients with age-related macular degeneration (AMD). DESIGN: A prospective, observational study. METHOD: Patients with AMD from an ophthalmologist's list (n = 135) completed the MacDQoL questionnaire by telephone interview and underwent a vision assessment on two occasions, one year apart. RESULTS: Among participants whose vision was stable over one year (n = 87), MacDQoL scores at baseline and follow-up were highly correlated (r = 0.95; P < .0001). Twelve of the 22 scale items had intraclass correlations of >.80; only two were correlated <.7. There was no difference between baseline and follow-up scores (P = .85), indicating excellent test-retest reliability. Poorer quality of life (QoL) at follow-up, measured by the MacDQoL present QoL overview item, was associated with deterioration in both the better eye and binocular distance visual acuity [VA] (r = 0.29; P = .001, r = 0.21; P = .016, respectively; n = 135). There was a positive correlation between deterioration in the Mac. DQoL average weighted impact score and deterioration in both binocular near VA and reading speed (r = 0.20; P = .019, r = 0.18; P = .041, respectively; n = 135). CONCLUSION: The MacDQoL has excellent test-retest reliability. Its sensitivity to change in vision status was demonstrated in correlational analyses. The measure indicates that the negative impact of AMD on QoL increases with increasing severity of visual impairment.

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