The neuropsychiatry of Gilles de la Tourette syndrome: The état de l'art

A. E. Cavanna*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Gilles de la Tourette syndrome (GTS) is a chronic tic disorder characterised by the presence of multiple motor and vocal tics with onset during development. Tics are the most common hyperkinetic symptoms in childhood and co-morbid behavioural conditions (especially obsessive-compulsive disorder, attention-deficit and hyperactivity disorder, affective symptoms, and impulsivity) are present in the majority of patients. Although GTS is no longer considered a rare medical curiosity, its exact pathophysiology remains elusive. Recent research on the brain correlates of the subjective ‘urge to tic’ has highlighted the role of extra-motor pathways within the brain mechanisms of tic generation. Advances in our understanding of the pathophysiology of GTS can pave the way to the implementation of more effective treatment strategies for this heterogeneous neurobehavioral condition. Finally, the development of GTS-specific instruments for the assessment of health-related quality of life has allowed more standardised assessments across the lifespan, capturing the impact of both tics and behavioural co-morbidities.

Original languageEnglish
JournalRevue Neurologique
Early online date8 Aug 2018
DOIs
Publication statusE-pub ahead of print - 8 Aug 2018

Fingerprint

Neuropsychiatry
Tics
Tourette Syndrome
Art
Tic Disorders
Efferent Pathways
Exploratory Behavior
Affective Symptoms
Impulsive Behavior
Obsessive-Compulsive Disorder
Brain
Attention Deficit Disorder with Hyperactivity
Quality of Life
Morbidity
Research

Keywords

  • Attention-deficit and hyperactivity disorder
  • Behaviour
  • Gilles de la Tourette syndrome
  • Health-related quality of life
  • Obsessive-compulsive disorder
  • Premonitory urges
  • Tics

Cite this

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The neuropsychiatry of Gilles de la Tourette syndrome : The état de l'art. / Cavanna, A. E.

In: Revue Neurologique, 08.08.2018.

Research output: Contribution to journalArticle

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