The number of the intraepithelial T cells correlate with the proliferation index in human bulbourethral gland epithelium

Tatiana V. Boronikhina; Gennadii A. Piavchenko; Artem A. Venediktov; Ekaterina Kustavinova; Svetlana G. Mukhamedova; Natalia Kartashkina; Sergey L. Kuznetsov; Igor Meglinski; Alexander N. Yatskovskiy

doi:10.1016/j.heliyon.2022.e11658

The number of the intraepithelial T cells correlate with the proliferation index in human bulbourethral gland epithelium

Tatiana V. Boronikhina, Gennadii A. Piavchenko^*, Artem A. Venediktov, Ekaterina Kustavinova, Svetlana G. Mukhamedova, Natalia Kartashkina, Sergey L. Kuznetsov, Igor Meglinski, Alexander N. Yatskovskiy

^*Corresponding author for this work

I. M. Sechenov First Moscow State Medical University

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: Our study has immunohistochemically examined T cells localization and number as well as proliferative activity level for the bulbourethral gland epithelium in men of different ages, using monoclonal antibodies against CD45RO and proliferating cell nuclear antigen (PCNA). Results: We have found that the T cells have been localized mainly in excretory ducts epithelium of the glands in any age group, meanwhile their relative number varies with age. The excretory ducts epithelium has shown a high proliferative activity when in acini the PCNA index has been low. Postnatal dynamics of the epithelium proliferative activity positively correlates with age-related density fluctuations in lymphocytic infiltration of the glands. Conclusions: We consider that intraepithelial T cells may contribute to the regulation of epithelial cells proliferation in the bulbourethral glands.

Original language	English
Article number	e11658
Number of pages	6
Journal	Heliyon
Volume	8
Issue number	11
Early online date	17 Nov 2022
DOIs	https://doi.org/10.1016/j.heliyon.2022.e11658
Publication status	Published - Nov 2022

Bibliographical note

Funding

Dr. Gennadii Piavchenko acknowledges the support of Ministry of Science and Higher Education of the Russian Federation [ 075-15-2020-926 ]. Prof. Igor Meglinski acknowledges the partial support of innovative programme [101004462] and the Leverhulme Trust and The Royal Society [APX111232 APEX Awards 2021] and the Academy of Finland [325097]. Dr. Gennadii Piavchenko and Prof. Igor Meglinski also acknowledge the support from the Academy of Finland [351068].

Keywords

Epithelial proliferation
Human bulbourethral glands
Lymphocytic infiltration
Proliferating cell nuclear antigen
T cells

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10.1016/j.heliyon.2022.e11658

The_number_of_the_intraepithelial_T_cells_correlate_with_the_proliferation
© 2022 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
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Boronikhina, T. V., Piavchenko, G. A., Venediktov, A. A., Kustavinova, E., Mukhamedova, S. G., Kartashkina, N., Kuznetsov, S. L., Meglinski, I., & Yatskovskiy, A. N. (2022). The number of the intraepithelial T cells correlate with the proliferation index in human bulbourethral gland epithelium. Heliyon, 8(11), Article e11658. https://doi.org/10.1016/j.heliyon.2022.e11658

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title = "The number of the intraepithelial T cells correlate with the proliferation index in human bulbourethral gland epithelium",

abstract = "Background: Our study has immunohistochemically examined T cells localization and number as well as proliferative activity level for the bulbourethral gland epithelium in men of different ages, using monoclonal antibodies against CD45RO and proliferating cell nuclear antigen (PCNA). Results: We have found that the T cells have been localized mainly in excretory ducts epithelium of the glands in any age group, meanwhile their relative number varies with age. The excretory ducts epithelium has shown a high proliferative activity when in acini the PCNA index has been low. Postnatal dynamics of the epithelium proliferative activity positively correlates with age-related density fluctuations in lymphocytic infiltration of the glands. Conclusions: We consider that intraepithelial T cells may contribute to the regulation of epithelial cells proliferation in the bulbourethral glands.",

keywords = "Epithelial proliferation, Human bulbourethral glands, Lymphocytic infiltration, Proliferating cell nuclear antigen, T cells",

author = "Boronikhina, {Tatiana V.} and Piavchenko, {Gennadii A.} and Venediktov, {Artem A.} and Ekaterina Kustavinova and Mukhamedova, {Svetlana G.} and Natalia Kartashkina and Kuznetsov, {Sergey L.} and Igor Meglinski and Yatskovskiy, {Alexander N.}",

note = "{\textcopyright} 2022 The Author(s).This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)",

year = "2022",

month = nov,

doi = "10.1016/j.heliyon.2022.e11658",

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T1 - The number of the intraepithelial T cells correlate with the proliferation index in human bulbourethral gland epithelium

AU - Boronikhina, Tatiana V.

AU - Piavchenko, Gennadii A.

AU - Venediktov, Artem A.

AU - Kustavinova, Ekaterina

AU - Mukhamedova, Svetlana G.

AU - Kartashkina, Natalia

AU - Kuznetsov, Sergey L.

AU - Meglinski, Igor

AU - Yatskovskiy, Alexander N.

PY - 2022/11

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N2 - Background: Our study has immunohistochemically examined T cells localization and number as well as proliferative activity level for the bulbourethral gland epithelium in men of different ages, using monoclonal antibodies against CD45RO and proliferating cell nuclear antigen (PCNA). Results: We have found that the T cells have been localized mainly in excretory ducts epithelium of the glands in any age group, meanwhile their relative number varies with age. The excretory ducts epithelium has shown a high proliferative activity when in acini the PCNA index has been low. Postnatal dynamics of the epithelium proliferative activity positively correlates with age-related density fluctuations in lymphocytic infiltration of the glands. Conclusions: We consider that intraepithelial T cells may contribute to the regulation of epithelial cells proliferation in the bulbourethral glands.

AB - Background: Our study has immunohistochemically examined T cells localization and number as well as proliferative activity level for the bulbourethral gland epithelium in men of different ages, using monoclonal antibodies against CD45RO and proliferating cell nuclear antigen (PCNA). Results: We have found that the T cells have been localized mainly in excretory ducts epithelium of the glands in any age group, meanwhile their relative number varies with age. The excretory ducts epithelium has shown a high proliferative activity when in acini the PCNA index has been low. Postnatal dynamics of the epithelium proliferative activity positively correlates with age-related density fluctuations in lymphocytic infiltration of the glands. Conclusions: We consider that intraepithelial T cells may contribute to the regulation of epithelial cells proliferation in the bulbourethral glands.

KW - Epithelial proliferation

KW - Human bulbourethral glands

KW - Lymphocytic infiltration

KW - Proliferating cell nuclear antigen

KW - T cells

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The number of the intraepithelial T cells correlate with the proliferation index in human bulbourethral gland epithelium

Abstract

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