The pharmacology of CGRP-responsive receptors in cultured and transfected cells

D.L. Hay; A.C. Conner; S.G. Howitt; M.A. Takhshid; J. Simms; K. Mahmoud; David Poyner

doi:10.1016/j.peptides.2004.06.007

The pharmacology of CGRP-responsive receptors in cultured and transfected cells

D.L. Hay
, A.C. Conner
, S.G. Howitt
, M.A. Takhshid
, J. Simms
, K. Mahmoud
, David Poyner

Aston University
University College Birmingham
Shiraz University of Medical Sciences
University of Auckland

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Historically, CGRP receptors have been classified as CGRP(1) or CGRP(2) subtypes, chiefly depending on their affinity for the antagonist CGRP(8-37). It has been shown that the complex between calcitonin receptor-like receptor (CRLR or CL) and receptor activity modifying protein (RAMP) 1 provides a molecular correlate for the CGRP(1) receptor; however this does not explain the range of affinities seen for CGRP(8-37) in isolated tissues. It is suggested that these may largely be explained by a combination of methodological factors and CGRP-responsive receptors generated by CL and RAMP2 or RAMP3 and complexes of RAMPs with the calcitonin receptor.

Original language	English
Pages (from-to)	2019-2026
Number of pages	8
Journal	Peptides
Volume	25
Issue number	11
DOIs	https://doi.org/10.1016/j.peptides.2004.06.007
Publication status	Published - 1 Nov 2004

Keywords

CGRP
calcitonin receptor-like receptor
RAMP1
RAMP2
RAMP3
CL
CGRP8–37
calcitonin receptor
BIBN4096BS

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10.1016/j.peptides.2004.06.007

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title = "The pharmacology of CGRP-responsive receptors in cultured and transfected cells",

abstract = "Historically, CGRP receptors have been classified as CGRP(1) or CGRP(2) subtypes, chiefly depending on their affinity for the antagonist CGRP(8-37). It has been shown that the complex between calcitonin receptor-like receptor (CRLR or CL) and receptor activity modifying protein (RAMP) 1 provides a molecular correlate for the CGRP(1) receptor; however this does not explain the range of affinities seen for CGRP(8-37) in isolated tissues. It is suggested that these may largely be explained by a combination of methodological factors and CGRP-responsive receptors generated by CL and RAMP2 or RAMP3 and complexes of RAMPs with the calcitonin receptor.",

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T1 - The pharmacology of CGRP-responsive receptors in cultured and transfected cells

AU - Hay, D.L.

AU - Conner, A.C.

AU - Howitt, S.G.

AU - Takhshid, M.A.

AU - Simms, J.

AU - Mahmoud, K.

AU - Poyner, David

PY - 2004/11/1

Y1 - 2004/11/1

N2 - Historically, CGRP receptors have been classified as CGRP(1) or CGRP(2) subtypes, chiefly depending on their affinity for the antagonist CGRP(8-37). It has been shown that the complex between calcitonin receptor-like receptor (CRLR or CL) and receptor activity modifying protein (RAMP) 1 provides a molecular correlate for the CGRP(1) receptor; however this does not explain the range of affinities seen for CGRP(8-37) in isolated tissues. It is suggested that these may largely be explained by a combination of methodological factors and CGRP-responsive receptors generated by CL and RAMP2 or RAMP3 and complexes of RAMPs with the calcitonin receptor.

AB - Historically, CGRP receptors have been classified as CGRP(1) or CGRP(2) subtypes, chiefly depending on their affinity for the antagonist CGRP(8-37). It has been shown that the complex between calcitonin receptor-like receptor (CRLR or CL) and receptor activity modifying protein (RAMP) 1 provides a molecular correlate for the CGRP(1) receptor; however this does not explain the range of affinities seen for CGRP(8-37) in isolated tissues. It is suggested that these may largely be explained by a combination of methodological factors and CGRP-responsive receptors generated by CL and RAMP2 or RAMP3 and complexes of RAMPs with the calcitonin receptor.

KW - CGRP

KW - calcitonin receptor-like receptor

KW - RAMP1

KW - RAMP2

KW - RAMP3

KW - CL

KW - CGRP8–37

KW - calcitonin receptor

KW - BIBN4096BS

UR - https://www.scopus.com/pages/publications/6344226602

UR - https://www.sciencedirect.com/science/article/pii/S019697810400258X?via%3Dihub

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DO - 10.1016/j.peptides.2004.06.007

M3 - Article

C2 - 15501536

SN - 0196-9781

VL - 25

SP - 2019

EP - 2026

JO - Peptides

JF - Peptides

IS - 11

ER -

The pharmacology of CGRP-responsive receptors in cultured and transfected cells

Abstract

Keywords

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