The psychological impact of diagnostic food challenges to confirm the resolution of peanut or tree nut allergy

R.C. Knibb, N.F. Ibrahim, G. Stiefel, R. Petley, A.J. Cummings, R.M. King, D. Keeton, L. Brown, M. Erlewyn-Lajeunesse, G. Roberts, J.S.A. Lucas

Research output: Contribution to journalArticle

Abstract

Background - Twenty percent of children outgrow peanut allergy and 10% outgrow tree nut allergy. Resolution can be confirmed by a food challenge. Little is known about the psychosocial impact of the challenge. We aimed to investigate effects of a food challenge on anxiety, stress and quality of life (QoL) in children and their mothers on the day of a food challenge to peanuts or nuts, and in the months following the challenge.
Methods - One hundred and three families participated. Forty children undergoing food challenges to access resolution of allergy, and their mothers, completed validated questionnaires to measure generic and food specific quality of life, stress and anxiety prior to challenge, on the day of investigation and 3–6 months later. Sixty-three children with no clinical indication to challenge (i.e. in the opinion of the allergist had persistent allergy) acted as comparison group completing questionnaires 3–6 months apart.
Results - Mothers reported raised anxiety on the day of challenge (P = 0.007), but children were less anxious. The children (P = 0.01) and mothers (P = 0.01) had improved food-related, but not general, QoL 3–6 months following challenge. Children reported lower anxiety levels following the challenge (P = 0.02), but anxiety remained unchanged in mothers. The improvements in maternal and children's QoL and anxiety levels were irrespective of the challenge outcome and despite co-existing food allergies in 50% of children.
Conclusions - Mothers experienced increased anxiety on the day of food challenge, unlike the children, perhaps reflecting the differences in their perceived risks. Food challenges are associated with improved food-related QoL in the following months even in those with a positive challenge.
LanguageEnglish
Pages451-459
Number of pages9
JournalClinical and Experimental Allergy
Volume42
Issue number3
Early online date15 Nov 2011
DOIs
Publication statusPublished - Mar 2012

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Nut Hypersensitivity
Psychology
Food
Anxiety
Mothers
Quality of Life
Food Quality
Hypersensitivity
Peanut Hypersensitivity
Arachis
Nuts
Food Hypersensitivity
Psychological Stress

Cite this

Knibb, R.C. ; Ibrahim, N.F. ; Stiefel, G. ; Petley, R. ; Cummings, A.J. ; King, R.M. ; Keeton, D. ; Brown, L. ; Erlewyn-Lajeunesse, M. ; Roberts, G. ; Lucas, J.S.A. / The psychological impact of diagnostic food challenges to confirm the resolution of peanut or tree nut allergy. In: Clinical and Experimental Allergy. 2012 ; Vol. 42, No. 3. pp. 451-459.
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Knibb, RC, Ibrahim, NF, Stiefel, G, Petley, R, Cummings, AJ, King, RM, Keeton, D, Brown, L, Erlewyn-Lajeunesse, M, Roberts, G & Lucas, JSA 2012, 'The psychological impact of diagnostic food challenges to confirm the resolution of peanut or tree nut allergy' Clinical and Experimental Allergy, vol. 42, no. 3, pp. 451-459. https://doi.org/10.1111/j.1365-2222.2011.03905.x

The psychological impact of diagnostic food challenges to confirm the resolution of peanut or tree nut allergy. / Knibb, R.C.; Ibrahim, N.F.; Stiefel, G.; Petley, R.; Cummings, A.J.; King, R.M.; Keeton, D.; Brown, L.; Erlewyn-Lajeunesse, M.; Roberts, G.; Lucas, J.S.A.

In: Clinical and Experimental Allergy, Vol. 42, No. 3, 03.2012, p. 451-459.

Research output: Contribution to journalArticle

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T1 - The psychological impact of diagnostic food challenges to confirm the resolution of peanut or tree nut allergy

AU - Knibb, R.C.

AU - Ibrahim, N.F.

AU - Stiefel, G.

AU - Petley, R.

AU - Cummings, A.J.

AU - King, R.M.

AU - Keeton, D.

AU - Brown, L.

AU - Erlewyn-Lajeunesse, M.

AU - Roberts, G.

AU - Lucas, J.S.A.

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N2 - Background - Twenty percent of children outgrow peanut allergy and 10% outgrow tree nut allergy. Resolution can be confirmed by a food challenge. Little is known about the psychosocial impact of the challenge. We aimed to investigate effects of a food challenge on anxiety, stress and quality of life (QoL) in children and their mothers on the day of a food challenge to peanuts or nuts, and in the months following the challenge.Methods - One hundred and three families participated. Forty children undergoing food challenges to access resolution of allergy, and their mothers, completed validated questionnaires to measure generic and food specific quality of life, stress and anxiety prior to challenge, on the day of investigation and 3–6 months later. Sixty-three children with no clinical indication to challenge (i.e. in the opinion of the allergist had persistent allergy) acted as comparison group completing questionnaires 3–6 months apart.Results - Mothers reported raised anxiety on the day of challenge (P = 0.007), but children were less anxious. The children (P = 0.01) and mothers (P = 0.01) had improved food-related, but not general, QoL 3–6 months following challenge. Children reported lower anxiety levels following the challenge (P = 0.02), but anxiety remained unchanged in mothers. The improvements in maternal and children's QoL and anxiety levels were irrespective of the challenge outcome and despite co-existing food allergies in 50% of children.Conclusions - Mothers experienced increased anxiety on the day of food challenge, unlike the children, perhaps reflecting the differences in their perceived risks. Food challenges are associated with improved food-related QoL in the following months even in those with a positive challenge.

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