The rational design of vaccines

Vincent W. Bramwell*, Yvonne Perrie

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


This review provides an insight into the various opportunities for vaccine intervention, analysis of strategies for vaccine development, vaccine ability to modulate immune responses and resultant rational vaccine design. In addition, wider aspects are considered, such as biotechnological advances, advances in immunological understanding and host-pathogen interactions. The key question addressed here is, with all our research and understanding, have we reached a new echelon in vaccine development, that of rational design? ©2005 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)1527-1534
Number of pages8
JournalDrug Discovery Today
Issue number22
Publication statusPublished - 15 Nov 2005


  • pharmaceutical science
  • drug discovery
  • immunology
  • biotechnology


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