The regulation of bacterial transcription initiation

Douglas F Browning, Stephen J Busby

Research output: Contribution to journalReview articlepeer-review


Bacteria use their genetic material with great effectiveness to make the right products in the correct amounts at the appropriate time. Studying bacterial transcription initiation in Escherichia coli has served as a model for understanding transcriptional control throughout all kingdoms of life. Every step in the pathway between gene and function is exploited to exercise this control, but for reasons of economy, it is plain that the key step to regulate is the initiation of RNA-transcript formation.

Original languageEnglish
Pages (from-to)57-65
Number of pages9
JournalNature Reviews: Microbiology
Issue number1
Publication statusPublished - 1 Jan 2004


  • Bacteria/genetics
  • Bacterial Proteins/genetics
  • Escherichia coli/genetics
  • Gene Expression Regulation, Bacterial
  • Promoter Regions, Genetic
  • Transcription, Genetic


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