The relationship between high-sensitivity CRP and polyclonal Free Light Chains as markers of inflammation in chronic disease

A. Burmeister, L.K. Assi, C.J. Ferro, R.G. Hughes, A.H. Barnett, S. Bellary, P. Cockwell, G. Pratt, C.A. Hutchison

Research output: Contribution to journalArticle

Abstract

Introduction: Serum concentrations of polyclonal free light chains (FLC) represent the activity of the adaptive immune system. This study assessed the relationship between polyclonal FLC and the established marker of innate immunity, C-reactive protein (CRP), in chronic and acute disease. Methods: We utilized four cross-sectional chronic disease patient cohorts: chronic kidney disease (CKD), diabetes, vasculitis and kidney transplantation; and a longitudinal intensive care case series to assess the kinetics of production in acute disease. Results: There was a weak association between polyclonal FLC and high-sensitivity CRP (hs-CRP) in the study cohorts. A longitudinal assessment in acute disease showed a gradual increase in FLC concentrations over time, often when CRP levels were falling, demonstrating clear differences in the response kinetics of CRP and FLC in this setting. Conclusion: Polyclonal FLC and hs-CRP provide independent information as to inflammatory status. Prospective studies are now required to assess the utility of hs-CRP and polyclonal FLC in combination for risk stratification in disease populations. © 2013 John Wiley & Sons Ltd.

Original languageEnglish
Pages (from-to)415-424
Number of pages10
JournalInternational Journal of Laboratory Hematology
Volume36
Issue number4
Early online date5 Nov 2013
DOIs
Publication statusPublished - 31 Aug 2014

Fingerprint

C-Reactive Protein
Chronic Disease
Inflammation
Light
Acute Disease
Accidental Falls
Kinetics
Immune system
Critical Care
Medical problems
Vasculitis
Nuclear Family
Chronic Renal Insufficiency
Innate Immunity
Kidney Transplantation
Immune System
Cohort Studies
Prospective Studies
Serum
Population

Keywords

  • c-reactive protein
  • inflammation
  • risk stratification
  • serum free light chains

Cite this

Burmeister, A. ; Assi, L.K. ; Ferro, C.J. ; Hughes, R.G. ; Barnett, A.H. ; Bellary, S. ; Cockwell, P. ; Pratt, G. ; Hutchison, C.A. / The relationship between high-sensitivity CRP and polyclonal Free Light Chains as markers of inflammation in chronic disease. In: International Journal of Laboratory Hematology. 2014 ; Vol. 36, No. 4. pp. 415-424.
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The relationship between high-sensitivity CRP and polyclonal Free Light Chains as markers of inflammation in chronic disease. / Burmeister, A.; Assi, L.K.; Ferro, C.J.; Hughes, R.G.; Barnett, A.H.; Bellary, S.; Cockwell, P.; Pratt, G.; Hutchison, C.A.

In: International Journal of Laboratory Hematology, Vol. 36, No. 4, 31.08.2014, p. 415-424.

Research output: Contribution to journalArticle

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T1 - The relationship between high-sensitivity CRP and polyclonal Free Light Chains as markers of inflammation in chronic disease

AU - Burmeister, A.

AU - Assi, L.K.

AU - Ferro, C.J.

AU - Hughes, R.G.

AU - Barnett, A.H.

AU - Bellary, S.

AU - Cockwell, P.

AU - Pratt, G.

AU - Hutchison, C.A.

PY - 2014/8/31

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N2 - Introduction: Serum concentrations of polyclonal free light chains (FLC) represent the activity of the adaptive immune system. This study assessed the relationship between polyclonal FLC and the established marker of innate immunity, C-reactive protein (CRP), in chronic and acute disease. Methods: We utilized four cross-sectional chronic disease patient cohorts: chronic kidney disease (CKD), diabetes, vasculitis and kidney transplantation; and a longitudinal intensive care case series to assess the kinetics of production in acute disease. Results: There was a weak association between polyclonal FLC and high-sensitivity CRP (hs-CRP) in the study cohorts. A longitudinal assessment in acute disease showed a gradual increase in FLC concentrations over time, often when CRP levels were falling, demonstrating clear differences in the response kinetics of CRP and FLC in this setting. Conclusion: Polyclonal FLC and hs-CRP provide independent information as to inflammatory status. Prospective studies are now required to assess the utility of hs-CRP and polyclonal FLC in combination for risk stratification in disease populations. © 2013 John Wiley & Sons Ltd.

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