The role of adipokines in beta-cell failure of type 2 diabetes

Simon J. Dunmore, James E. Brown

Research output: Contribution to journalArticle

Abstract

Beta-cell failure coupled with insulin resistance is a key factor in the development of type 2 diabetes. Changes in circulating levels of adipokines, factors released from adipose tissue, form a significant link between excessive adiposity in obesity and both aforementioned factors. In this review we consider the published evidence for the role of individual adipokines on the function, proliferation, death and failure of beta-cells, focusing on those reported to have the most significant effects (leptin, adiponectin, TNFa, resistin, visfatin, DPP-IV and apelin). It is apparent that some adipokines have beneficial effects whereas others have detrimental properties; the overall contribution to beta-cell failure of changed concentrations of adipokines in the blood of obese pre-diabetic subjects will be highly dependent on the balance between these effects and the interactions between the adipokines which act on the beta-cell via a number of intersecting intracellular signalling pathways. We emphasise the importance, and comparative dearth, of studies into the combined effects of adipokines on beta-cells.
LanguageEnglish
PagesT37-T45
Number of pages9
JournalJournal of Endocrinology
Volume216
Issue number1
Early online date18 Sep 2012
DOIs
Publication statusPublished - 2012

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Adipokines
Type 2 Diabetes Mellitus
Nicotinamide Phosphoribosyltransferase
Resistin
Adiponectin
Adiposity
Leptin
Insulin Resistance
Adipose Tissue
Obesity

Cite this

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The role of adipokines in beta-cell failure of type 2 diabetes. / Dunmore, Simon J.; Brown, James E.

In: Journal of Endocrinology, Vol. 216, No. 1, 2012, p. T37-T45.

Research output: Contribution to journalArticle

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