The role of ERK5 in endothelial cell function

Gopika N. Nithianandarajah-Jones, Bettina Wilm, Christopher E.P. Goldring, Jürgen Müller, Michael J. Cross*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Extracellular-signal-regulated kinase 5 (ERK5), also termed big MAPK1 (BMK1), is the most recently discovered member of the mitogen-activated protein kinase (MAPK) family. It is expressed in a variety of tissues and is activated by a range of growth factors, cytokines and cellular stresses. Targeted deletion of Erk5 in mice has revealed that the ERK5 signalling cascade is critical for normal cardiovascular development and vascular integrity. In vitro studies have revealed that, in endothelial cells, ERK5 is required for preventing apoptosis, mediating shear-stress signalling and regulating tumour angiogenesis. The present review focuses on our current understanding of the role of ERK5 in regulating endothelial cell function.

Original languageEnglish
Pages (from-to)1584-1589
Number of pages6
JournalBiochemical Society Transactions
Volume42
Issue number6
DOIs
Publication statusPublished - 1 Dec 2014

Bibliographical note

© The Authors Journal compilation © 2014 Biochemical Society.
This verion is not the final peer-reviewed Version of Record.

Keywords

  • angiogenesis big MAPK1 (BMK1)
  • endothelial cell
  • extracellular-signal-regulated kinase 5 (ERK5)
  • mitogen-activated protein kinase (MAPK)
  • signal transduction

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    Nithianandarajah-Jones, G. N., Wilm, B., Goldring, C. E. P., Müller, J., & Cross, M. J. (2014). The role of ERK5 in endothelial cell function. Biochemical Society Transactions, 42(6), 1584-1589. https://doi.org/10.1042/BST20140276