The selective protection afforded by ebselen against lipid peroxidation in an ROS-dependent model of inflammation

Helen R. Griffiths, E.J. Dowling, T. Sahinoglu, D Blake, M. Parnham, Joseph Lunec

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of an experimental model of hydrogen-peroxide-induced foot pad oedema on indices of oxidative damage to biomolecules have been investigated. We have demonstrated increased levels of fluorescent protein and lipid peroxides occurring in plasma at 24 and 48 h post-injection. In addition, a decrease in the degree of galactosylation of IgG was observed which kinetically related the degree of inflammation and to the increase in protein autofluorescence (a specific index of oxidative damage). The effects of ebselen, a novel organoselenium compound which protects against oxidative tissue injury in a glutathione-peroxidase-like manner, have also been examined in this model. Pretreatment of animals with a dose of 50 mg/kg ebselen afforded significant and selective protection against lipid peroxidation only. This effect may contribute to the anti-inflammatory effect of this agent in hydroperoxide-linked tissue damage.
Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalInflammation Research
Volume36
Issue number1-2
DOIs
Publication statusPublished - May 1992

Keywords

  • hydrogen-peroxide-induced foot pad oedema
  • oxidative damage
  • biomolecules
  • fluorescent protein
  • lipid peroxides
  • galactosylation
  • ebselen
  • organoselenium compound
  • oxidative tissue injury

Fingerprint Dive into the research topics of 'The selective protection afforded by ebselen against lipid peroxidation in an ROS-dependent model of inflammation'. Together they form a unique fingerprint.

Cite this