The study of synchronization of rhythms of microvascular blood flow and oxygen saturation during adaptive changes

Andrey V. Dunaev; Victor V. Sidorov; Alexander I. Krupatkin; Ilya E. Rafailov; Scott G. Palmer; Sergei G. Sokolovski; Neil A. Stewart; Edik U. Rafailov

doi:10.1117/12.2035748

The study of synchronization of rhythms of microvascular blood flow and oxygen saturation during adaptive changes

Andrey V. Dunaev, Victor V. Sidorov, Alexander I. Krupatkin, Ilya E. Rafailov, Scott G. Palmer, Sergei G. Sokolovski, Neil A. Stewart, Edik U. Rafailov

Aston Institute of Photonic Technologies (AiPT)

Research output: Chapter in Book/Published conference output › Conference publication

Abstract

Multi-functional laser non-invasive diagnostic systems, such as "LAKK-M", allow the study of a number of microcirculatory parameters, including blood microcirculatory index (I_m) (by laser Doppler flowmetry, LDF) and oxygen saturation (S_tO₂) of skin tissue (by tissue reflectance oximetry, TRO). Such systems may provide significant information relevant to physiology and clinical medicine. The aim of this research was to use such a system to study the synchronization of microvascular blood flow and oxygen saturation rhythms under normal and adaptive change conditions. Studies were conducted with 8 healthy volunteers - 3 females and 5 males of 21-49 years. Each volunteer was subjected to basic 3 minute tests. The volunteers were observed for between 1-4 months each, totalling 422 basic tests. Measurements were performed on the palmar surface of the right middle finger and the forearm medial surface. Wavelet analysis was used to study rhythmic oscillations in LDF- and TRO-data. Tissue oxygen consumption (from arterial and venal blood oxygen saturation and nutritive flux volume) was calculated for all volunteers during "adaptive changes" as (617±123 AU) and (102±38 AU) with and without arteriovenous anastomoses (AVAs) respectively. This demonstrates increased consumption compared to normal (495±170 AU) and (69±40 AU) with and without AVAs respectively. Data analysis demonstrated the emergence of resonance and synchronization of rhythms of microvascular blood flow and oxygen saturation as an adaptive change in myogenic oscillation (vasomotion) resulting from exercise and potentially from psychoemotional stress. Synchronization of myogenic rhythms during adaptive changes suggest increased oxygen consumption resulting from increased microvascular blood flow velocity.

Original language	English
Title of host publication	Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XII
Publisher	SPIE
Volume	8935
ISBN (Print)	9780819498489
DOIs	https://doi.org/10.1117/12.2035748
Publication status	Published - 1 Jan 2014
Event	Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XII - San Francisco, CA, United States Duration: 2 Feb 2014 → 4 Feb 2014

Conference

Conference	Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XII
Country/Territory	United States
City	San Francisco, CA
Period	2/02/14 → 4/02/14

Bibliographical note

Keywords

Adaptive changes
Laser Doppler flowmetry
Oxygen consumption
Tissue reflectance oximetry
Vasomotion

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10.1117/12.2035748

rhythms of microvascular blood flow
© (2014) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE).
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Cite this

Dunaev, A. V., Sidorov, V. V., Krupatkin, A. I., Rafailov, I. E., Palmer, S. G., Sokolovski, S. G., Stewart, N. A., & Rafailov, E. U. (2014). The study of synchronization of rhythms of microvascular blood flow and oxygen saturation during adaptive changes. In Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XII (Vol. 8935). Article 89350A SPIE. https://doi.org/10.1117/12.2035748

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abstract = "Multi-functional laser non-invasive diagnostic systems, such as {"}LAKK-M{"}, allow the study of a number of microcirculatory parameters, including blood microcirculatory index (Im) (by laser Doppler flowmetry, LDF) and oxygen saturation (StO2) of skin tissue (by tissue reflectance oximetry, TRO). Such systems may provide significant information relevant to physiology and clinical medicine. The aim of this research was to use such a system to study the synchronization of microvascular blood flow and oxygen saturation rhythms under normal and adaptive change conditions. Studies were conducted with 8 healthy volunteers - 3 females and 5 males of 21-49 years. Each volunteer was subjected to basic 3 minute tests. The volunteers were observed for between 1-4 months each, totalling 422 basic tests. Measurements were performed on the palmar surface of the right middle finger and the forearm medial surface. Wavelet analysis was used to study rhythmic oscillations in LDF- and TRO-data. Tissue oxygen consumption (from arterial and venal blood oxygen saturation and nutritive flux volume) was calculated for all volunteers during {"}adaptive changes{"} as (617±123 AU) and (102±38 AU) with and without arteriovenous anastomoses (AVAs) respectively. This demonstrates increased consumption compared to normal (495±170 AU) and (69±40 AU) with and without AVAs respectively. Data analysis demonstrated the emergence of resonance and synchronization of rhythms of microvascular blood flow and oxygen saturation as an adaptive change in myogenic oscillation (vasomotion) resulting from exercise and potentially from psychoemotional stress. Synchronization of myogenic rhythms during adaptive changes suggest increased oxygen consumption resulting from increased microvascular blood flow velocity.",

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author = "Dunaev, {Andrey V.} and Sidorov, {Victor V.} and Krupatkin, {Alexander I.} and Rafailov, {Ilya E.} and Palmer, {Scott G.} and Sokolovski, {Sergei G.} and Stewart, {Neil A.} and Rafailov, {Edik U.}",

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Dunaev, AV, Sidorov, VV, Krupatkin, AI, Rafailov, IE, Palmer, SG, Sokolovski, SG, Stewart, NA & Rafailov, EU 2014, The study of synchronization of rhythms of microvascular blood flow and oxygen saturation during adaptive changes. in Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XII. vol. 8935, 89350A, SPIE, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XII, San Francisco, CA, United States, 2/02/14. https://doi.org/10.1117/12.2035748

The study of synchronization of rhythms of microvascular blood flow and oxygen saturation during adaptive changes. / Dunaev, Andrey V.; Sidorov, Victor V.; Krupatkin, Alexander I. et al.
Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XII. Vol. 8935 SPIE, 2014. 89350A.

Research output: Chapter in Book/Published conference output › Conference publication

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T1 - The study of synchronization of rhythms of microvascular blood flow and oxygen saturation during adaptive changes

AU - Dunaev, Andrey V.

AU - Sidorov, Victor V.

AU - Krupatkin, Alexander I.

AU - Rafailov, Ilya E.

AU - Palmer, Scott G.

AU - Sokolovski, Sergei G.

AU - Stewart, Neil A.

AU - Rafailov, Edik U.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Multi-functional laser non-invasive diagnostic systems, such as "LAKK-M", allow the study of a number of microcirculatory parameters, including blood microcirculatory index (Im) (by laser Doppler flowmetry, LDF) and oxygen saturation (StO2) of skin tissue (by tissue reflectance oximetry, TRO). Such systems may provide significant information relevant to physiology and clinical medicine. The aim of this research was to use such a system to study the synchronization of microvascular blood flow and oxygen saturation rhythms under normal and adaptive change conditions. Studies were conducted with 8 healthy volunteers - 3 females and 5 males of 21-49 years. Each volunteer was subjected to basic 3 minute tests. The volunteers were observed for between 1-4 months each, totalling 422 basic tests. Measurements were performed on the palmar surface of the right middle finger and the forearm medial surface. Wavelet analysis was used to study rhythmic oscillations in LDF- and TRO-data. Tissue oxygen consumption (from arterial and venal blood oxygen saturation and nutritive flux volume) was calculated for all volunteers during "adaptive changes" as (617±123 AU) and (102±38 AU) with and without arteriovenous anastomoses (AVAs) respectively. This demonstrates increased consumption compared to normal (495±170 AU) and (69±40 AU) with and without AVAs respectively. Data analysis demonstrated the emergence of resonance and synchronization of rhythms of microvascular blood flow and oxygen saturation as an adaptive change in myogenic oscillation (vasomotion) resulting from exercise and potentially from psychoemotional stress. Synchronization of myogenic rhythms during adaptive changes suggest increased oxygen consumption resulting from increased microvascular blood flow velocity.

AB - Multi-functional laser non-invasive diagnostic systems, such as "LAKK-M", allow the study of a number of microcirculatory parameters, including blood microcirculatory index (Im) (by laser Doppler flowmetry, LDF) and oxygen saturation (StO2) of skin tissue (by tissue reflectance oximetry, TRO). Such systems may provide significant information relevant to physiology and clinical medicine. The aim of this research was to use such a system to study the synchronization of microvascular blood flow and oxygen saturation rhythms under normal and adaptive change conditions. Studies were conducted with 8 healthy volunteers - 3 females and 5 males of 21-49 years. Each volunteer was subjected to basic 3 minute tests. The volunteers were observed for between 1-4 months each, totalling 422 basic tests. Measurements were performed on the palmar surface of the right middle finger and the forearm medial surface. Wavelet analysis was used to study rhythmic oscillations in LDF- and TRO-data. Tissue oxygen consumption (from arterial and venal blood oxygen saturation and nutritive flux volume) was calculated for all volunteers during "adaptive changes" as (617±123 AU) and (102±38 AU) with and without arteriovenous anastomoses (AVAs) respectively. This demonstrates increased consumption compared to normal (495±170 AU) and (69±40 AU) with and without AVAs respectively. Data analysis demonstrated the emergence of resonance and synchronization of rhythms of microvascular blood flow and oxygen saturation as an adaptive change in myogenic oscillation (vasomotion) resulting from exercise and potentially from psychoemotional stress. Synchronization of myogenic rhythms during adaptive changes suggest increased oxygen consumption resulting from increased microvascular blood flow velocity.

KW - Adaptive changes

KW - Laser Doppler flowmetry

KW - Oxygen consumption

KW - Tissue reflectance oximetry

KW - Vasomotion

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DO - 10.1117/12.2035748

M3 - Conference publication

AN - SCOPUS:84897011227

SN - 9780819498489

VL - 8935

BT - Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XII

PB - SPIE

T2 - Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XII

Y2 - 2 February 2014 through 4 February 2014

ER -

The study of synchronization of rhythms of microvascular blood flow and oxygen saturation during adaptive changes

Abstract

Conference

Bibliographical note

Keywords

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