The use of computational QSAR analysis in the toxicological evaluation of a series of 2-pyridylcarboxamidrazone candidate anti-tuberculosis compounds

Keyphrases

• Antitubercular 33%
• Antituberculosis Compound 100%
• Attenuated Toxicity 33%
• Benzylidene 33%
• Benzyloxy 66%
• Common Mode 33%
• Computational Analysis 33%
• Cytotoxicity 66%
• Dimethyl Sulfoxide 33%
• Dimethylamino 33%
• Ethoxy 33%
• Glutathione 33%
• High Activity 33%
• Hydrophobicity 33%
• Ionization Potential 33%
• Low Toxicity 33%
• Methoxy 100%
• Mononuclear Leukocytes 33%
• N-acetylcysteine 66%
• Nitro 33%
• Pyridine-2 33%
• QSAR Analysis 100%
• Quantitative Structure-activity Relationship 33%
• R2 Value 33%
• Rank Order 33%
• Secondary Mechanisms 33%
• Thiols 33%
• Toxicants 33%
• Toxicity Mechanism 33%
• Toxicological Evaluation 100%

Pharmacology, Toxicology and Pharmaceutical Science

• Acetylcysteine 50%
• Antitubercular Activity 25%
• Cytotoxicity 50%
• Dimethyl Sulfoxide 25%
• Glutathione 25%
• Hydrophobicity 25%
• Isoniazid 100%
• QSAR Study 25%
• Quantitative Structure Activity Relation 100%
• Thiol 25%
• Toxic Agent 25%