Thermoresponsive polysarcosine-based nanoparticles

Huayang Yu, Nicola Ingram, Jason V. Rowley, Sam Parkinson, David C. Green, Nicholas J. Warren, Paul D. Thornton

Research output: Contribution to journalArticlepeer-review

Abstract

Polysarcosine holds great promise as an alternative to poly(ethylene glycol) for use within both biomedical and non-biomedical applications owing to its hydrophilicity and non-cytoxicity, amongst other features. The grafting of a limited quantity of (N-(2-hydroxypropyl)methacrylamide) to polysarcosine, for instance 3.5% of the total copolymer in terms of the number of repeat units, has a profound effect on the properties of the copolymer formed; polymer self-assembly to yield thermoreponsive nanoparticles can now be realised. Such nanoparticles are non-cytotoxic against a range of human breast cancer cell lines, able to withhold the therapeutic compound doxorubicin, and allow pronounced doxorubicin release in response to subtle thermal stimulation. This research informs of how the straightforward modification of polysarcosine with a nominal molar amount of poly(N-(2-hydroxypropyl)methacrylamide) can yield stimuli-responsive polymers that are suitable for use within controlled release applications.

Original languageEnglish
Pages (from-to)4217-4223
JournalJournal of Materials Chemistry B
Volume7
Issue number26
Early online date5 Jun 2019
DOIs
Publication statusPublished - 2019

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