Thiosemicarbazones active against Clostridium difficile

Cait Costello, Tarja Karpanen, Peter A. Lambert, Preena Mistry, Katy J. Parker, Daniel L. Rathbone, Jiangmeng Ren, Laura Wheeldon, Tony Worthington

Research output: Contribution to journalArticle

Abstract

A set of closely related furylidene thiosemicarbazones was prepared and screened against various clinically important Gram-positive bacteria. One compound containing an ethylene spacer and a 5-nitrofuryl group was found to have promising activity against Clostridium difficile.
Original languageEnglish
Pages (from-to)1708-1711
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number5
DOIs
Publication statusPublished - 1 Mar 2008

Fingerprint

Thiosemicarbazones
Clostridium
Clostridium difficile
Gram-Positive Bacteria
Bacteria
ethylene

Bibliographical note

NOTICE: this is the author’s version of a work that was accepted for publication in Bioorganic and Medicinal Chemistry Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Costello, Cait; Karpanen, Tarja; Lambert, Peter A.; Mistry, Preena; Parker, Katy J.; Rathbone, Daniel L.; Ren, Jiangmeng; Wheeldon, Laura and Worthington, Tony (2008). Thiosemicarbazones active against Clostridium difficile. Bioorganic and Medicinal Chemistry Letters, 18 (5), pp. 1708-1711. DOI 10.1016/j.bmcl.2008.01.041

Keywords

  • thiosemicarbazone
  • Clostridium difficile
  • antimicrobial
  • nitrofuran

Cite this

Costello, Cait ; Karpanen, Tarja ; Lambert, Peter A. ; Mistry, Preena ; Parker, Katy J. ; Rathbone, Daniel L. ; Ren, Jiangmeng ; Wheeldon, Laura ; Worthington, Tony. / Thiosemicarbazones active against Clostridium difficile. In: Bioorganic and Medicinal Chemistry Letters. 2008 ; Vol. 18, No. 5. pp. 1708-1711.
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Thiosemicarbazones active against Clostridium difficile. / Costello, Cait; Karpanen, Tarja; Lambert, Peter A.; Mistry, Preena; Parker, Katy J.; Rathbone, Daniel L.; Ren, Jiangmeng; Wheeldon, Laura; Worthington, Tony.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 18, No. 5, 01.03.2008, p. 1708-1711.

Research output: Contribution to journalArticle

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