Three-dimensional calibration targets for optical coherence tomography

Michelle G. Sandrian, Peter H. Tomlins, Peter D. Woolliams, Janarthanan Rasakanthan, Graham C.B. Lee, Anna Yang, Boris Považay, Aneesh Alex, Kate Sugden, Wolfgang Drexler

Research output: Chapter in Book/Report/Conference proceedingConference publication

Abstract

The recent expansion of clinical applications for optical coherence tomography (OCT) is driving the development of approaches for consistent image acquisition. There is a simultaneous need for time-stable, easy-to-use imaging targets for calibration and standardization of OCT devices. We present calibration targets consisting of three-dimensional structures etched into nanoparticle-embedded resin. Spherical iron oxide nanoparticles with a predominant particle diameter of 400 nm were homogeneously dispersed in a two part polyurethane resin and allowed to harden overnight. These samples were then etched using a precision micromachining femtosecond laser with a center wavelength of 1026 nm, 100kHz repetition rate and 450 fs pulse duration. A series of lines in depth were etched, varying the percentage of inscription energy and speed of the translation stage moving the target with respect to the laser. Samples were imaged with a dual wavelength spectral-domain OCT system and point-spread function of nanoparticles within the target was measured.
Original languageEnglish
Title of host publicationOptical diagnostics and sensing XII
Subtitle of host publicationtoward point-of-care diagnostics; and design and performance validation of phantoms used in conjunction with optical measurement of tissue IV
EditorsRobert J. Nordstrom, Gerard L. Coté
PublisherSPIE
Number of pages7
Volume8229
DOIs
Publication statusPublished - Jan 2012
EventOptical diagnostics and sensing XII: Toward Point-of-Care Diagnostics; and design and performance validation of phantoms used in conjunction with optical measurement of tissue IV - San Francisco, CA, United States
Duration: 21 Jan 2012 → …

Publication series

NameSPIE proceedings
PublisherSPIE
Volume8229
ISSN (Print)0277-786X

Conference

ConferenceOptical diagnostics and sensing XII: Toward Point-of-Care Diagnostics; and design and performance validation of phantoms used in conjunction with optical measurement of tissue IV
CountryUnited States
CitySan Francisco, CA
Period21/01/12 → …

Bibliographical note

Sandrian, Michelle G.; Tomlins, Peter H.; Woolliams, Peter D.; Rasakanthan, Janarthanan; Lee, Graham C.B.; Yang, Anna; Považay, Boris; Alex, Aneesh; Sugden, Kate; Drexler, Wolfgang, "Three-dimensional calibration targets for optical coherence tomography". Optical diagnostics and sensing XII: toward point-of-care diagnostics; and design and performance validation of phantoms used in conjunction with optical measurement of tissue IV., ed. Robert J. Nordstrom; Gerard L. Coté. Vol. 8229 SPIE, 2012. (SPIE proceedings).

Copyright 2012 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic electronic or print reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

http://dx.doi.org/10.1117/12.907748

Keywords

  • calibration target
  • optical coherence tomography
  • femtosecond inscription
  • point-spread function

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    Sandrian, M. G., Tomlins, P. H., Woolliams, P. D., Rasakanthan, J., Lee, G. C. B., Yang, A., Považay, B., Alex, A., Sugden, K., & Drexler, W. (2012). Three-dimensional calibration targets for optical coherence tomography. In R. J. Nordstrom, & G. L. Coté (Eds.), Optical diagnostics and sensing XII: toward point-of-care diagnostics; and design and performance validation of phantoms used in conjunction with optical measurement of tissue IV (Vol. 8229). (SPIE proceedings; Vol. 8229). SPIE. https://doi.org/10.1117/12.907748