Three-dimensional fluid pressure mapping in porous media using magnetic resonance imaging with gas-filled liposomes

Robert H. Morris*, Martin Bencsik, Anil K. Vangala, Yvonne Perrie

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

This paper presents and demonstrates a method for using magnetic resonance imaging to measure local pressure of a fluid saturating a porous medium. The method is tested both in a static system of packed silica gel and in saturated sintered glass cylinders experiencing fluid flow. The fluid used contains 3% gas in the form of 3-μm average diameter gas filled 1,2-distearoyl-sn-glycero-3-phosphocholine (C18:0, MW: 790.16) liposomes suspended in 5% glycerol and 0.5% Methyl cellulose with water. Preliminary studies at 2.35 T demonstrate relative magnetic resonance signal changes of 20% per bar in bulk fluid for an echo time TE=40 ms, and 6-10% in consolidated porous media for TE=10 ms, over the range 0.8-1.8 bar for a spatial resolution of 0.1 mm3 and a temporal resolution of 30 s. The stability of this solution with relation to applied pressure and methods for improving sensitivity are discussed. © 2007 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)509-512
Number of pages4
JournalMagnetic Resonance Imaging
Volume25
Issue number4
DOIs
Publication statusPublished - May 2007
Event8th International Bologna Conferene on Magnetic Resonance in Porous Media - Bologna, Italy
Duration: 10 Sep 2006 → …

Keywords

  • contrast agent
  • liposome
  • microbubble
  • MRI
  • porous medium
  • pressure

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