Time-series based evaluation of physiological alterations in age-associated frailty during walking at self-selected velocity

L. A. Álvarez-Millán; D. Castillo-Castillo; A. Pérez-Pacheco; R. Quispe-Siccha; M. Angelova; J. Rivera-Sánchez; R. Fossion

doi:10.1063/1.5095917

Time-series based evaluation of physiological alterations in age-associated frailty during walking at self-selected velocity

L. A. Álvarez-Millán^*, D. Castillo-Castillo, A. Pérez-Pacheco, R. Quispe-Siccha, M. Angelova, J. Rivera-Sánchez, R. Fossion

^*Corresponding author for this work

Research output: Chapter in Book/Published conference output › Conference publication

2 Citations (Scopus)

Abstract

Medical prognosis is based on symptoms, such as loss of functionality or a deviation of the average value of physiological parameters from their adequate homeostatic ranges. On the other hand, alterations in physiological regulation may precede the appearance of symptoms, as has been suggested in geriatrics in the case of age-associated frailty. Technological advances allow to monitor in a continuous and non-invasive way a large variety of physiological variables and it has been proposed that the statistics of the resulting time series reflects the dynamics of these underlying regulatory processes. The purpose of the present contribution is to explore the relation between medical frailty scales and time series of continuous physiological monitoring in relation to medical prognosis during a physical effort test of walking 160m at a self-selected velocity in selected subjects of young adults, non-frail elderly adults and frail elderly adults.

Original language	English
Title of host publication	XV Mexican Symposium on Medical Physics
Editors	Carlos-Gerardo Trevino-Palacios, Karla-Paola Garcia-Pelagio, Olga-Leticia Avila-Aguirre, Ruben Fossion, Maria-Ester Brandan, Mariana Hernandez-Bojorquez
ISBN (Electronic)	9780735418202
DOIs	https://doi.org/10.1063/1.5095917
Publication status	Published - 10 Apr 2019
Event	15th Mexican Symposium on Medical Physics - Mexico City, Mexico Duration: 13 Jun 2018 → 15 Jun 2018

Publication series

Name	AIP Conference Proceedings
Volume	2090
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	15th Mexican Symposium on Medical Physics
Country/Territory	Mexico
City	Mexico City
Period	13/06/18 → 15/06/18

Bibliographical note

Publisher Copyright:
© 2019 Author(s).

Funding

We wish to thank all the participants of this study and to Catalina Ramírez for her valuable help with the collocation of the monitoring devices and patient management. Financial funding for this work was supplied by the Dirección General de Asuntos del Personal Académico (DGAPA) from the Universidad Nacional Autónoma de México (UNAM) with grants PAPIIT IV100116 and IA105017. We are also gratefully acknowledged grants 2015-02-1093, 2016-01-2277 and CB-2011-01-167441 from the Consejo Nacional de Ciencia y Tecnología (CONACyT). We are thankful for the Newton Advanced Fellowship Awarded to RF by the Academy of Medical Sciences through the UK Government´s Newton Fund Program. RF is grateful to J.P.J. Fossion for fruitful discussions.

Funders	Funder number
Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México
UK Government´s Newton Fund Program
Academy of Medical Sciences
Consejo Nacional de Ciencia y Tecnología
Universidad Nacional Autónoma de México	CB-2011-01-167441, 2016-01-2277, PAPIIT IV100116, 2015-02-1093, IA105017

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Cite this

Álvarez-Millán, L. A., Castillo-Castillo, D., Pérez-Pacheco, A., Quispe-Siccha, R., Angelova, M., Rivera-Sánchez, J., & Fossion, R. (2019). Time-series based evaluation of physiological alterations in age-associated frailty during walking at self-selected velocity. In C.-G. Trevino-Palacios, K.-P. Garcia-Pelagio, O.-L. Avila-Aguirre, R. Fossion, M.-E. Brandan, & M. Hernandez-Bojorquez (Eds.), XV Mexican Symposium on Medical Physics Article 050002 (AIP Conference Proceedings; Vol. 2090). https://doi.org/10.1063/1.5095917

Álvarez-Millán, L. A. ; Castillo-Castillo, D. ; Pérez-Pacheco, A. et al. / Time-series based evaluation of physiological alterations in age-associated frailty during walking at self-selected velocity. XV Mexican Symposium on Medical Physics. editor / Carlos-Gerardo Trevino-Palacios ; Karla-Paola Garcia-Pelagio ; Olga-Leticia Avila-Aguirre ; Ruben Fossion ; Maria-Ester Brandan ; Mariana Hernandez-Bojorquez. 2019. (AIP Conference Proceedings).

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title = "Time-series based evaluation of physiological alterations in age-associated frailty during walking at self-selected velocity",

abstract = "Medical prognosis is based on symptoms, such as loss of functionality or a deviation of the average value of physiological parameters from their adequate homeostatic ranges. On the other hand, alterations in physiological regulation may precede the appearance of symptoms, as has been suggested in geriatrics in the case of age-associated frailty. Technological advances allow to monitor in a continuous and non-invasive way a large variety of physiological variables and it has been proposed that the statistics of the resulting time series reflects the dynamics of these underlying regulatory processes. The purpose of the present contribution is to explore the relation between medical frailty scales and time series of continuous physiological monitoring in relation to medical prognosis during a physical effort test of walking 160m at a self-selected velocity in selected subjects of young adults, non-frail elderly adults and frail elderly adults.",

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Álvarez-Millán, LA, Castillo-Castillo, D, Pérez-Pacheco, A, Quispe-Siccha, R, Angelova, M, Rivera-Sánchez, J & Fossion, R 2019, Time-series based evaluation of physiological alterations in age-associated frailty during walking at self-selected velocity. in C-G Trevino-Palacios, K-P Garcia-Pelagio, O-L Avila-Aguirre, R Fossion, M-E Brandan & M Hernandez-Bojorquez (eds), XV Mexican Symposium on Medical Physics., 050002, AIP Conference Proceedings, vol. 2090, 15th Mexican Symposium on Medical Physics, Mexico City, Mexico, 13/06/18. https://doi.org/10.1063/1.5095917

Time-series based evaluation of physiological alterations in age-associated frailty during walking at self-selected velocity. / Álvarez-Millán, L. A.; Castillo-Castillo, D.; Pérez-Pacheco, A. et al.
XV Mexican Symposium on Medical Physics. ed. / Carlos-Gerardo Trevino-Palacios; Karla-Paola Garcia-Pelagio; Olga-Leticia Avila-Aguirre; Ruben Fossion; Maria-Ester Brandan; Mariana Hernandez-Bojorquez. 2019. 050002 (AIP Conference Proceedings; Vol. 2090).

Research output: Chapter in Book/Published conference output › Conference publication

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AU - Álvarez-Millán, L. A.

AU - Castillo-Castillo, D.

AU - Pérez-Pacheco, A.

AU - Quispe-Siccha, R.

AU - Angelova, M.

AU - Rivera-Sánchez, J.

AU - Fossion, R.

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AB - Medical prognosis is based on symptoms, such as loss of functionality or a deviation of the average value of physiological parameters from their adequate homeostatic ranges. On the other hand, alterations in physiological regulation may precede the appearance of symptoms, as has been suggested in geriatrics in the case of age-associated frailty. Technological advances allow to monitor in a continuous and non-invasive way a large variety of physiological variables and it has been proposed that the statistics of the resulting time series reflects the dynamics of these underlying regulatory processes. The purpose of the present contribution is to explore the relation between medical frailty scales and time series of continuous physiological monitoring in relation to medical prognosis during a physical effort test of walking 160m at a self-selected velocity in selected subjects of young adults, non-frail elderly adults and frail elderly adults.

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Álvarez-Millán LA, Castillo-Castillo D, Pérez-Pacheco A, Quispe-Siccha R, Angelova M, Rivera-Sánchez J et al. Time-series based evaluation of physiological alterations in age-associated frailty during walking at self-selected velocity. In Trevino-Palacios CG, Garcia-Pelagio KP, Avila-Aguirre OL, Fossion R, Brandan ME, Hernandez-Bojorquez M, editors, XV Mexican Symposium on Medical Physics. 2019. 050002. (AIP Conference Proceedings). doi: 10.1063/1.5095917

Time-series based evaluation of physiological alterations in age-associated frailty during walking at self-selected velocity

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