Time–frequency analysis of laser speckle contrast for transcranial assessment of cerebral blood flow

Nadezhda Golubova; Elena Potapova; Evgeniya Seryogina; Viktor Dremin

doi:10.1016/j.bspc.2023.104969

Time–frequency analysis of laser speckle contrast for transcranial assessment of cerebral blood flow

Nadezhda Golubova, Elena Potapova, Evgeniya Seryogina, Viktor Dremin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Improving noninvasive approaches to monitoring blood microcirculation is an urgent topic in modern biomedical engineering. One of the actively developing methods is laser speckle contrast imaging (LSCI), which allows not only the visualization of microvessels but also the quantitative measurements of microcirculatory blood flow. This work shows the application of LSCI for mapping the cerebral vessels of a laboratory animal, and also presents the time–frequency processing of the registered signal. Thus, we expand the capabilities of the existing LSCI approach and demonstrate spatial mapping of blood flow rhythms. The proposed technology makes it possible not only to measure the relative cerebral blood flow but also to expand diagnostic capabilities for a detailed analysis of the physiological mechanisms of changes in blood flow.

Original language	English
Article number	104969
Number of pages	7
Journal	Biomedical Signal Processing and Control
Volume	85
DOIs	https://doi.org/10.1016/j.bspc.2023.104969
Publication status	Published - 25 Apr 2023

Bibliographical note

Funding Information:
The study was supported by the Russian Science Foundation, Russia under the project No. 22-75-10088 .

Publisher Copyright: © 2023 Elsevier Ltd

Keywords

Cerebral blood flow dynamics
Laser speckle contrast imaging
Wavelet transform

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10.1016/j.bspc.2023.104969

Cite this

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title = "Time–frequency analysis of laser speckle contrast for transcranial assessment of cerebral blood flow",

abstract = "Improving noninvasive approaches to monitoring blood microcirculation is an urgent topic in modern biomedical engineering. One of the actively developing methods is laser speckle contrast imaging (LSCI), which allows not only the visualization of microvessels but also the quantitative measurements of microcirculatory blood flow. This work shows the application of LSCI for mapping the cerebral vessels of a laboratory animal, and also presents the time–frequency processing of the registered signal. Thus, we expand the capabilities of the existing LSCI approach and demonstrate spatial mapping of blood flow rhythms. The proposed technology makes it possible not only to measure the relative cerebral blood flow but also to expand diagnostic capabilities for a detailed analysis of the physiological mechanisms of changes in blood flow.",

keywords = "Cerebral blood flow dynamics, Laser speckle contrast imaging, Wavelet transform",

author = "Nadezhda Golubova and Elena Potapova and Evgeniya Seryogina and Viktor Dremin",

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T1 - Time–frequency analysis of laser speckle contrast for transcranial assessment of cerebral blood flow

AU - Golubova, Nadezhda

AU - Potapova, Elena

AU - Seryogina, Evgeniya

AU - Dremin, Viktor

PY - 2023/4/25

Y1 - 2023/4/25

N2 - Improving noninvasive approaches to monitoring blood microcirculation is an urgent topic in modern biomedical engineering. One of the actively developing methods is laser speckle contrast imaging (LSCI), which allows not only the visualization of microvessels but also the quantitative measurements of microcirculatory blood flow. This work shows the application of LSCI for mapping the cerebral vessels of a laboratory animal, and also presents the time–frequency processing of the registered signal. Thus, we expand the capabilities of the existing LSCI approach and demonstrate spatial mapping of blood flow rhythms. The proposed technology makes it possible not only to measure the relative cerebral blood flow but also to expand diagnostic capabilities for a detailed analysis of the physiological mechanisms of changes in blood flow.

AB - Improving noninvasive approaches to monitoring blood microcirculation is an urgent topic in modern biomedical engineering. One of the actively developing methods is laser speckle contrast imaging (LSCI), which allows not only the visualization of microvessels but also the quantitative measurements of microcirculatory blood flow. This work shows the application of LSCI for mapping the cerebral vessels of a laboratory animal, and also presents the time–frequency processing of the registered signal. Thus, we expand the capabilities of the existing LSCI approach and demonstrate spatial mapping of blood flow rhythms. The proposed technology makes it possible not only to measure the relative cerebral blood flow but also to expand diagnostic capabilities for a detailed analysis of the physiological mechanisms of changes in blood flow.

KW - Cerebral blood flow dynamics

KW - Laser speckle contrast imaging

KW - Wavelet transform

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Time–frequency analysis of laser speckle contrast for transcranial assessment of cerebral blood flow

Abstract

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Keywords

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