Tocotrienols, health and ageing: A systematic review

Ekavi N. Georgousopoulou, Demosthenes B. Panagiotakos, Duane D. Mellor, Nenad Naumovski

Research output: Contribution to journalReview article

Abstract

Objectives
A systematic review of studies was undertaken to evaluate the potential effect of intake of tocotrienols or circulating levels of tocotrienols on parameters associated with successful ageing, specifically in relation to cognitive function, osteoporosis and DNA damage.

Methods
Following PRISMA guidelines a systematic review of epidemiological observational studies and clinical trials was undertaken. Inclusion criteria included all English language publications in the databases PubMed and Scopus, through to the end of July 2016.

Results
Evidence from prospective and case-control studies suggested that increased blood levels of tocotrienols were associated with favorable cognitive function outcomes. A clinical trial of tocotrienol supplementation for 6 months suggested a beneficial effect of intake on DNA damage rates, but only in elderly people. Regarding osteoporosis, only in vitro studies with cultures of human bone cells were identified, and these demonstrated significant inhibition of osteoclast activity and promotion of osteoblast activity.

Conclusions
Research in middle-aged and elderly humans suggests that tocotrienols have a potential beneficial anti-ageing action with respect to cognitive impairment and DNA damage. Clinical trials are required to elucidate these effects.
Original languageEnglish
Pages (from-to)55-60
JournalMaturitas
Volume95
Early online date9 Nov 2016
DOIs
Publication statusPublished - 1 Jan 2017

Bibliographical note

© 2016, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

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    Georgousopoulou, E. N., Panagiotakos, D. B., Mellor, D. D., & Naumovski, N. (2017). Tocotrienols, health and ageing: A systematic review. Maturitas, 95, 55-60. https://doi.org/10.1016/j.maturitas.2016.11.003