Transglutaminase 2 cross-linking of matrix proteins: biological significance and medical applications

Research output: Contribution to journalArticle

Abstract

This review summarises the functions of the enzyme tissue transglutaminase (TG2) in the extracellular matrix (ECM) both as a matrix stabiliser through its protein cross-linking activity and as an important cell adhesion protein involved in cell survival. The contribution of extracellular TG2 to the pathology of important diseases such as cancer and fibrosis are discussed with a view to the potential importance of TG2 as a therapeutic target. The medical applications of TG2 are further expanded by detailing the use of transglutaminase cross-linking in the development of novel biocompatible biomaterials for use in soft and hard tissue repair.
LanguageEnglish
Pages659-670
Number of pages12
JournalAmino Acids
Volume36
Issue number4
DOIs
Publication statusPublished - Apr 2009

Fingerprint

Medical applications
Transglutaminases
Cell adhesion
Biocompatible Materials
Pathology
Cell Adhesion
Extracellular Matrix
Cell Survival
Proteins
Fibrosis
Repair
Cells
Tissue
Enzymes
Neoplasms
transglutaminase 2
Therapeutics

Bibliographical note

9th Conference on Transglutaminase and Protein Crosslinking, Marrakesh, Monaco, September 2007

Keywords

  • tissue transglutaminase
  • TG2
  • biomaterials
  • extracellular matrix
  • cross-linking

Cite this

@article{edfac88a657d4437992efe2abdc72f58,
title = "Transglutaminase 2 cross-linking of matrix proteins: biological significance and medical applications",
abstract = "This review summarises the functions of the enzyme tissue transglutaminase (TG2) in the extracellular matrix (ECM) both as a matrix stabiliser through its protein cross-linking activity and as an important cell adhesion protein involved in cell survival. The contribution of extracellular TG2 to the pathology of important diseases such as cancer and fibrosis are discussed with a view to the potential importance of TG2 as a therapeutic target. The medical applications of TG2 are further expanded by detailing the use of transglutaminase cross-linking in the development of novel biocompatible biomaterials for use in soft and hard tissue repair.",
keywords = "tissue transglutaminase, TG2, biomaterials, extracellular matrix, cross-linking",
author = "Russell Collighan and Martin Griffin",
note = "9th Conference on Transglutaminase and Protein Crosslinking, Marrakesh, Monaco, September 2007",
year = "2009",
month = "4",
doi = "10.1007/s00726-008-0190-y",
language = "English",
volume = "36",
pages = "659--670",
journal = "Amino Acids",
issn = "0939-4451",
publisher = "Springer",
number = "4",

}

Transglutaminase 2 cross-linking of matrix proteins: biological significance and medical applications. / Collighan, Russell; Griffin, Martin.

In: Amino Acids, Vol. 36, No. 4, 04.2009, p. 659-670.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Transglutaminase 2 cross-linking of matrix proteins: biological significance and medical applications

AU - Collighan, Russell

AU - Griffin, Martin

N1 - 9th Conference on Transglutaminase and Protein Crosslinking, Marrakesh, Monaco, September 2007

PY - 2009/4

Y1 - 2009/4

N2 - This review summarises the functions of the enzyme tissue transglutaminase (TG2) in the extracellular matrix (ECM) both as a matrix stabiliser through its protein cross-linking activity and as an important cell adhesion protein involved in cell survival. The contribution of extracellular TG2 to the pathology of important diseases such as cancer and fibrosis are discussed with a view to the potential importance of TG2 as a therapeutic target. The medical applications of TG2 are further expanded by detailing the use of transglutaminase cross-linking in the development of novel biocompatible biomaterials for use in soft and hard tissue repair.

AB - This review summarises the functions of the enzyme tissue transglutaminase (TG2) in the extracellular matrix (ECM) both as a matrix stabiliser through its protein cross-linking activity and as an important cell adhesion protein involved in cell survival. The contribution of extracellular TG2 to the pathology of important diseases such as cancer and fibrosis are discussed with a view to the potential importance of TG2 as a therapeutic target. The medical applications of TG2 are further expanded by detailing the use of transglutaminase cross-linking in the development of novel biocompatible biomaterials for use in soft and hard tissue repair.

KW - tissue transglutaminase

KW - TG2

KW - biomaterials

KW - extracellular matrix

KW - cross-linking

UR - http://www.scopus.com/inward/record.url?scp=62949217561&partnerID=8YFLogxK

UR - http://www.springerlink.com/content/283125vr04886127/?p=7f0b8defff6a4551899466477578e3db&pi=0

U2 - 10.1007/s00726-008-0190-y

DO - 10.1007/s00726-008-0190-y

M3 - Article

VL - 36

SP - 659

EP - 670

JO - Amino Acids

T2 - Amino Acids

JF - Amino Acids

SN - 0939-4451

IS - 4

ER -