Transglutaminase and vascular biology: physiopathologic implications and perspectives for therapeutic interventions

Carlo M. Bergamini, Martin Griffin, Francesco S. Pansini

Research output: Contribution to journalArticle

Abstract

Consistent clinical and experimental evidence points to the involvement of two enzymatic systems (the matrix metalloproteinases-MMPs and the protein crosslinking enzymes transglutaminases) in prominent physiologic roles of endothelium in the maintenance of vascular wall integrity, regulation of blood flow and clotting, and exchange of molecules and cells between the extra- and the intravascular space. These issues are briefly discussed in relation to differentiation of the endothelium within the vascular system, mechanisms of molecular regulation and the effects of their disruption in pathology. While the roles of MMPs are now understood in detail and represent a promising target for pharmacological interventions, much less is known on the roles of transglutaminases in vascular biology. These last enzymes are expressed at extremely high levels in endothelial cells and are involved in cell matrix interactions important to angiogenesis and apoptosis/cell death of endothelial cells, in the control of blood clotting and and in the transfer of molecules and cells across the vascular walls. On the clinical side, these properties are relevant in vascular inflammatory processes, atherosclerosis and tumor metastasis. We summarise the large body of evidence available in this perspective and discuss its implications for the development of new therapeutic strategies.
Original languageEnglish
Pages (from-to)2357-2372
Number of pages16
JournalCurrent Medicinal Chemistry
Volume12
Issue number20
DOIs
Publication statusPublished - 2005

Keywords

  • endothelium
  • extracellular matrix
  • transglutaminases
  • atherosclerosis
  • tumor metastasis

Fingerprint Dive into the research topics of 'Transglutaminase and vascular biology: physiopathologic implications and perspectives for therapeutic interventions'. Together they form a unique fingerprint.

  • Cite this