Target-specific delivery has become an integral area of research in order to increase bioavailability and reduce the toxic effects of drugs. As a drug-delivery option, trigger-release liposomes offer sophisticated targeting and greater control-release capabilities. These are broadly divided into two categories; those that utilise the local environment of the target site where there may be an upregulation in certain enzymes or a change in pH and those liposomes that are triggered by an external physical stimulus such as heat, ultrasound or light. These release mechanisms offer a greater degree of control over when and where the drug is released; furthermore, targeting of diseased tissue is enhanced by incorporation of target-specific components such as antibodies. This review aims to show the development of such trigger release liposome systems and the current research in this field.
- trigger release
- enzyme-triggered release
Bibi, S., Lattmann, E., Mohammed, A-U-R., & Perrie, Y. (2012). Trigger release liposome systems: local and remote controlled delivery? Journal of Microencapsulation, 29(3), 262-276. https://doi.org/10.3109/02652048.2011.646330