Trigger release liposome systems: local and remote controlled delivery?

Sagida Bibi, Eric Lattmann, Afzal-Ur-Rahman Mohammed, Yvonne Perrie

Research output: Contribution to journalArticle

Abstract

Target-specific delivery has become an integral area of research in order to increase bioavailability and reduce the toxic effects of drugs. As a drug-delivery option, trigger-release liposomes offer sophisticated targeting and greater control-release capabilities. These are broadly divided into two categories; those that utilise the local environment of the target site where there may be an upregulation in certain enzymes or a change in pH and those liposomes that are triggered by an external physical stimulus such as heat, ultrasound or light. These release mechanisms offer a greater degree of control over when and where the drug is released; furthermore, targeting of diseased tissue is enhanced by incorporation of target-specific components such as antibodies. This review aims to show the development of such trigger release liposome systems and the current research in this field.
Original languageEnglish
Pages (from-to)262-276
Number of pages15
JournalJournal of Microencapsulation
Volume29
Issue number3
DOIs
Publication statusPublished - May 2012

Keywords

  • vesicles
  • liposomes
  • trigger release
  • photosensitive
  • ultrasound
  • enzyme-triggered release
  • thermosensitive

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