Type 2 diabetes and cardiovascular risk in the UK south Asian community

A. H. Barnett*, A. N. Dixon, S. Bellary, M. W. Hanif, J. P. O'Hare, N. T. Raymond, S. Kumar

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

A popular hypothesis for the greater prevalence of type 2 diabetes and cardiovascular disease in UK south Asians is that they have an increased susceptibility of developing insulin resistance in response to certain environmental factors, including obesity and adoption of a sedentary lifestyle. Insulin resistance is postulated as a central feature of the metabolic syndrome, culminating in type 2 diabetes, atherosclerotic vascular disease and CHD; a pathway potentially accelerated by migration/urbanisation. We describe and compare the prevalence of type 2 diabetes, cardiovascular disease and their associated risk factors in UK south Asian and white Caucasian populations to determine possible reasons for the increased preponderance of these diseases in south Asians, and highlight key evidence for optimal risk factor management. Finally, we describe a UK community-based programme that attempts to reduce the morbidity and mortality from type 2 diabetes and cardiovascular disease in south Asians through a new approach to management.

Original languageEnglish
Pages (from-to)2234-2246
Number of pages13
JournalDiabetologia
Volume49
Issue number10
DOIs
Publication statusPublished - Oct 2006

Keywords

  • Cardiovascular disease
  • Ethnic
  • Metabolic syndrome
  • Migration
  • Risk factors
  • South Asian
  • Type 2 diabetes

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