Type 2 diabetes in adolescents and young adults

Nadia Lascar, James Brown, Helen Pattison, Anthony H. Barnett, Clifford J. Bailey, Srikanth Bellary

Research output: Contribution to journalArticle

Abstract

The prevalence of type 2 diabetes in adolescents and young adults is dramatically increasing. Similar to older-onset type 2 diabetes, the major predisposing risk factors are obesity, family history, and sedentary lifestyle. Onset of diabetes at a younger age (defined here as up to age 40 years) is associated with longer disease exposure and increased risk for chronic complications. Young-onset type 2 diabetes also affects more individuals of working age, accentuating the adverse societal effects of the disease. Furthermore, evidence is accumulating that young-onset type 2 diabetes has a more aggressive disease phenotype, leading to premature development of complications, with adverse effects on quality of life and unfavourable effects on long-term outcomes, raising the possibility of a future public health catastrophe. In this Review, we describe the epidemiology and existing knowledge regarding pathophysiology, risk factors, complications, and management of type 2 diabetes in adolescents and young adults.

LanguageEnglish
JournalThe Lancet Diabetes and Endocrinology
Volumein press
Early online date15 Aug 2017
DOIs
Publication statusPublished - 5 Oct 2017

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Type 2 Diabetes Mellitus
Young Adult
Sedentary Lifestyle
Risk Management
Causality
Epidemiology
Public Health
Obesity
Quality of Life
Phenotype

Bibliographical note

© 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

Cite this

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Type 2 diabetes in adolescents and young adults. / Lascar, Nadia; Brown, James; Pattison, Helen; Barnett, Anthony H.; Bailey, Clifford J.; Bellary, Srikanth.

In: The Lancet Diabetes and Endocrinology, Vol. in press, 05.10.2017.

Research output: Contribution to journalArticle

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