Type 2 diabetes in adolescents and young adults

Nadia Lascar; James Brown; Helen Pattison; Anthony H. Barnett; Clifford J. Bailey; Srikanth Bellary

doi:10.1016/S2213-8587(17)30186-9

Type 2 diabetes in adolescents and young adults

Nadia Lascar, James Brown, Helen Pattison, Anthony H. Barnett, Clifford J. Bailey, Srikanth Bellary^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

The prevalence of type 2 diabetes in adolescents and young adults is dramatically increasing. Similar to older-onset type 2 diabetes, the major predisposing risk factors are obesity, family history, and sedentary lifestyle. Onset of diabetes at a younger age (defined here as up to age 40 years) is associated with longer disease exposure and increased risk for chronic complications. Young-onset type 2 diabetes also affects more individuals of working age, accentuating the adverse societal effects of the disease. Furthermore, evidence is accumulating that young-onset type 2 diabetes has a more aggressive disease phenotype, leading to premature development of complications, with adverse effects on quality of life and unfavourable effects on long-term outcomes, raising the possibility of a future public health catastrophe. In this Review, we describe the epidemiology and existing knowledge regarding pathophysiology, risk factors, complications, and management of type 2 diabetes in adolescents and young adults.

Original language	English
Pages (from-to)	69-80
Number of pages	12
Journal	The Lancet Diabetes and Endocrinology
Volume	6
Issue number	1
Early online date	25 Aug 2017
DOIs	https://doi.org/10.1016/S2213-8587(17)30186-9
Publication status	Published - 1 Jan 2018

Bibliographical note

Keywords

Diabetes
Type 2

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10.1016/S2213-8587(17)30186-9

Type 2 diabetes in adolescents and young adults
© 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Accepted author manuscript, 791 KBLicence: CC BY-NC-ND 3.0

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AU - Lascar, Nadia

AU - Brown, James

AU - Pattison, Helen

AU - Barnett, Anthony H.

AU - Bailey, Clifford J.

AU - Bellary, Srikanth

PY - 2018/1/1

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AB - The prevalence of type 2 diabetes in adolescents and young adults is dramatically increasing. Similar to older-onset type 2 diabetes, the major predisposing risk factors are obesity, family history, and sedentary lifestyle. Onset of diabetes at a younger age (defined here as up to age 40 years) is associated with longer disease exposure and increased risk for chronic complications. Young-onset type 2 diabetes also affects more individuals of working age, accentuating the adverse societal effects of the disease. Furthermore, evidence is accumulating that young-onset type 2 diabetes has a more aggressive disease phenotype, leading to premature development of complications, with adverse effects on quality of life and unfavourable effects on long-term outcomes, raising the possibility of a future public health catastrophe. In this Review, we describe the epidemiology and existing knowledge regarding pathophysiology, risk factors, complications, and management of type 2 diabetes in adolescents and young adults.

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Type 2 diabetes in adolescents and young adults

Abstract

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Keywords

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