Ultra-endurance exercise: unanswered questions in redox biology and immunology

James E. Turner, Stuart J. Bennett, Jos A. Bosch, Helen R. Griffiths, Sarah Aldred

Research output: Contribution to journalArticle

Abstract

Ultra-endurance races are extreme exercise events that can take place over large parts of a day, several consecutive days or over weeks and months interspersed by periods of rest and recovery. Since the first ultraendurance races in the late 1970s, around 1000 races are now held worldwide each year, and more than 100000 people take part. Although these athletes appear to be fit and healthy, there have been occasional reports of severe complications following ultra-endurance exercise. Thus there is concern that repeated extreme exercise events could have deleterious effects on health, which might be brought about by the high levels of ROS (reactive oxygen species) produced during exercise. Studies that have examined biomarkers of oxidative damage following ultra-endurance exercise have found measurements to be elevated for several days, which has usually been interpreted to reflect increased ROS production. Levels of the antioxidant molecule GSH (reduced glutathione) are depleted for 1 month or longer following ultra-endurance exercise, suggesting an impaired capacity to copewith ROS. The present paper summarizes studies that have examined the oxidative footprint of ultra-endurance exercise in light of current thinking in redox biology and the possible health implications of such extreme exercise. © The Authors Journal compilation © 2014 Biochemical Society.

LanguageEnglish
Pages989-895
Number of pages7
JournalBiochemical Society Transactions
Volume42
Issue number4
DOIs
Publication statusPublished - 31 Aug 2014

Fingerprint

Immunology
Allergy and Immunology
Oxidation-Reduction
Durability
Exercise
Reactive Oxygen Species
Health
Biomarkers
Glutathione
Antioxidants
Recovery
Molecules
Athletes

Keywords

  • antioxidant
  • glutathione
  • oxidative stress
  • peroxiredoxin
  • protein oxidation
  • reactive oxygen species

Cite this

Turner, J. E., Bennett, S. J., Bosch, J. A., Griffiths, H. R., & Aldred, S. (2014). Ultra-endurance exercise: unanswered questions in redox biology and immunology. Biochemical Society Transactions, 42(4), 989-895. https://doi.org/10.1042/BST20140120
Turner, James E. ; Bennett, Stuart J. ; Bosch, Jos A. ; Griffiths, Helen R. ; Aldred, Sarah. / Ultra-endurance exercise : unanswered questions in redox biology and immunology. In: Biochemical Society Transactions. 2014 ; Vol. 42, No. 4. pp. 989-895.
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Turner, JE, Bennett, SJ, Bosch, JA, Griffiths, HR & Aldred, S 2014, 'Ultra-endurance exercise: unanswered questions in redox biology and immunology' Biochemical Society Transactions, vol. 42, no. 4, pp. 989-895. https://doi.org/10.1042/BST20140120

Ultra-endurance exercise : unanswered questions in redox biology and immunology. / Turner, James E.; Bennett, Stuart J.; Bosch, Jos A.; Griffiths, Helen R.; Aldred, Sarah.

In: Biochemical Society Transactions, Vol. 42, No. 4, 31.08.2014, p. 989-895.

Research output: Contribution to journalArticle

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