Ultrashort pulsed laser in deep head tissues penetration for non-invasive optogenetics in near-IR windows

Diana Galiakhmetova; Viktor Dremin; Aleksandr Koviarov; Dmitrii Stoliarov; Neville Ngum; Rheinallt Parri; Sergei Sokolovski; Edik Rafailov

doi:10.1117/12.2666376

Ultrashort pulsed laser in deep head tissues penetration for non-invasive optogenetics in near-IR windows

Diana Galiakhmetova, Viktor Dremin, Aleksandr Koviarov, Dmitrii Stoliarov, Neville Ngum, Rheinallt Parri, Sergei Sokolovski, Edik Rafailov

Research output: Unpublished contribution to conference › Other

Abstract

Optogenetic control of neuronal activity requires efficient light energy transmission through head tissues and bone. Here we evaluate the efficiency of ultrashort pulsed and continuous-wave light transmittance through the mouse scalp, skull, and brain tissues in near-IR optical windows. The outcomes of the experiments and computer modelling show that the brain cortex tissues can be exposed to 10-12% of the original laser irradiation. This finding together with the latest discovery of non-linear phytochrome conversion [S.Sokolovski et al. 2021] prove the possibility of phytochrome optogenetics in living animals and may be applied in the future for non-invasive photo-controlling of neural cells.

Original language	English
DOIs	https://doi.org/10.1117/12.2666376
Publication status	Published - 6 Mar 2023

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title = "Ultrashort pulsed laser in deep head tissues penetration for non-invasive optogenetics in near-IR windows",

abstract = "Optogenetic control of neuronal activity requires efficient light energy transmission through head tissues and bone. Here we evaluate the efficiency of ultrashort pulsed and continuous-wave light transmittance through the mouse scalp, skull, and brain tissues in near-IR optical windows. The outcomes of the experiments and computer modelling show that the brain cortex tissues can be exposed to 10-12% of the original laser irradiation. This finding together with the latest discovery of non-linear phytochrome conversion [S.Sokolovski et al. 2021] prove the possibility of phytochrome optogenetics in living animals and may be applied in the future for non-invasive photo-controlling of neural cells.",

author = "Diana Galiakhmetova and Viktor Dremin and Aleksandr Koviarov and Dmitrii Stoliarov and Neville Ngum and Rheinallt Parri and Sergei Sokolovski and Edik Rafailov",

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T1 - Ultrashort pulsed laser in deep head tissues penetration for non-invasive optogenetics in near-IR windows

AU - Galiakhmetova, Diana

AU - Dremin, Viktor

AU - Koviarov, Aleksandr

AU - Stoliarov, Dmitrii

AU - Ngum, Neville

AU - Parri, Rheinallt

AU - Sokolovski, Sergei

AU - Rafailov, Edik

PY - 2023/3/6

Y1 - 2023/3/6

N2 - Optogenetic control of neuronal activity requires efficient light energy transmission through head tissues and bone. Here we evaluate the efficiency of ultrashort pulsed and continuous-wave light transmittance through the mouse scalp, skull, and brain tissues in near-IR optical windows. The outcomes of the experiments and computer modelling show that the brain cortex tissues can be exposed to 10-12% of the original laser irradiation. This finding together with the latest discovery of non-linear phytochrome conversion [S.Sokolovski et al. 2021] prove the possibility of phytochrome optogenetics in living animals and may be applied in the future for non-invasive photo-controlling of neural cells.

AB - Optogenetic control of neuronal activity requires efficient light energy transmission through head tissues and bone. Here we evaluate the efficiency of ultrashort pulsed and continuous-wave light transmittance through the mouse scalp, skull, and brain tissues in near-IR optical windows. The outcomes of the experiments and computer modelling show that the brain cortex tissues can be exposed to 10-12% of the original laser irradiation. This finding together with the latest discovery of non-linear phytochrome conversion [S.Sokolovski et al. 2021] prove the possibility of phytochrome optogenetics in living animals and may be applied in the future for non-invasive photo-controlling of neural cells.

UR - https://www.spiedigitallibrary.org/conference-proceedings-of-spie/PC12373/2666376/Ultrashort-pulsed-laser-in-deep-head-tissues-penetration-for-non/10.1117/12.2666376.short

U2 - 10.1117/12.2666376

DO - 10.1117/12.2666376

M3 - Other

ER -

Ultrashort pulsed laser in deep head tissues penetration for non-invasive optogenetics in near-IR windows

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