Understanding the challenges faced by adolescents and young adults with allergic conditions: a systematic review

Marta Vazquez-Ortiz; Elizabeth Angier; Katharina Blumchen; Pasquale Comberiati; Bettina Duca; Audrey DunnGalvin; Claudia Gore; Valérie Hox; Britt Jensen; Helena Pite; Alexandra F Santos; Silvia Sanchez; Cherry Alviani; Teresa Garriga-Baraut; Rebecca Knibb; Charlotte G Mortz; M Hazel Gowland; Frans Timmermans; Graham Roberts

doi:10.1111/all.14258

Understanding the challenges faced by adolescents and young adults with allergic conditions: a systematic review

Marta Vazquez-Ortiz
, Elizabeth Angier
, Katharina Blumchen
, Pasquale Comberiati
, Bettina Duca
, Audrey DunnGalvin
, Claudia Gore
, Valérie Hox
, Britt Jensen
, Helena Pite
, Alexandra F Santos
, Silvia Sanchez
, Cherry Alviani
, Teresa Garriga-Baraut
, Rebecca Knibb
, Charlotte G Mortz
, M Hazel Gowland
, Frans Timmermans
, Graham Roberts

School of Psychology

Department of Paediatrics, Faculty of Medicine, Imperial College London, United Kingdom.
Primary Care and Population Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Department of Paediatric and Adolescent Medicine, Paediatric Pneumology, Allergology and Cystic Fibrosis, University Hospital Frankfurt, Frankfurt am Main, Germany.
Department of Clinical Immunology and Allergology, I.M. Sechenov First Moscow State Medical University, 119991, Moscow, Russia.
Department Paediatrics, Imperial College London, UK.
Paediatrics and Child Infectious Diseases, First Moscow State Medical University, Russia.
Department of Paediatrics, Imperial College Healthcare NHS Trust, London, UK.
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospitals Saint-Luc, Brussels, Belgium.
Department of Dermatology and Allergy Centre, Odense Research Centre for Anaphylaxis (ORCA), Odense University Hospital, University of Southern Denmark, Odense, Denmark.
CEDOC, Chronic Diseases Research Center, NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal.
Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom.
Allergy Department, Hospital Infantil Universitario del Niño Jesús, Madrid, Spain.
The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Isle of Wight, UK.
Grup d'Investigació "Creixement i Desenvolupament", Institut de Recerca de l'Hospital Universitari Vall d'Hebron (VHIR), Barcelona, Spain.
Allergy Action, St Albans, UK.
Frans Timmermans, Nederlands Anafylaxis Netwerk - European Anaphylaxis Taskforce, Dordrecht, The Netherlands.
MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, SO16 6YD, UK; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Research output: Contribution to journal › Review article › peer-review

72 Citations (Scopus)

23 Downloads (Pure)

Abstract

BACKGROUND: Adolescence represents a vulnerable time for individuals with asthma and allergic conditions. They suffer an unexpected degree of morbidity. This systematic review aimed to understand the challenges faced by adolescents and young adults with these conditions.

METHODS: A systematic literature search was undertaken across eight databases. References were checked by two reviewers for inclusion. Study data were extracted, and their quality was assessed in duplicate. A narrative meta-synthesis was undertaken.

RESULTS: A total of 108 papers describing 106 studies were retrieved, most focused on asthma. Five themes were identified across studies: (a) Health-related quality of life-impairment was associated with poor disease control, psychosocial issues, adolescent-onset allergic disease and female sex; (b) Psychological factors-asthma and food allergy were associated with anxiety and depression, atopic dermatitis was associated with suicidal ideation, and that parental emotional support may be protective; (c) Adherence-suboptimal adherence was associated with older age, barriers to medication usage, poor symptom perception and failure to take responsibility, and positive factors were routines, simpler treatment regimes, better knowledge and perceptions about medications; (d) Self-management-facilitated by education, knowledge and a positive attitude; and (e) Supportive relationships-families could modify barriers to adherence and foster positive views about self-management, adolescents suggested that their peers should be more involved in supporting them, and adolescents also wished to have support from nonjudgemental healthcare professionals.

CONCLUSIONS: We have some understanding of the challenges faced by adolescents with asthma, less so for other allergic conditions. This knowledge will be used to support guidelines for managing adolescents.

Original language	English
Pages (from-to)	1850-1880
Number of pages	31
Journal	Allergy
Volume	75
Issue number	8
Early online date	6 Mar 2020
DOIs	https://doi.org/10.1111/all.14258
Publication status	Published - 1 Aug 2020

Bibliographical note

This is the peer reviewed version of the following article: Vazquez‐Ortiz, M., Angier, E., Blumchen, K., Comberiati, P., Duca, B., DunnGalvin, A., Gore, C., Hox, V., Jensen, B., Pite, H., Santos, A.F., Sanchez, S., Alviani, C., Garriga‐Baraut, T., Knibb, R., Mortz, C.G., Gowland, M.H., Timmermans, F. and Roberts, G. (2020), Understanding the challenges faced by adolescents and young adults with allergic conditions: a systematic review. Allergy. Accepted Author Manuscript., which has been published in final form at https://doi.org/10.1111/all.14258. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

adolescent
allergy
asthma
food allergy
rhinoconjunctivitis
transition
young adult

Access to Document

10.1111/all.14258

Understanding the challenges faced by adolescent
This is the peer reviewed version of the following article: Vazquez‐Ortiz, M., Angier, E., Blumchen, K., Comberiati, P., Duca, B., DunnGalvin, A., Gore, C., Hox, V., Jensen, B., Pite, H., Santos, A.F., Sanchez, S., Alviani, C., Garriga‐Baraut, T., Knibb, R., Mortz, C.G., Gowland, M.H., Timmermans, F. and Roberts, G. (2020), Understanding the challenges faced by adolescents and young adults with allergic conditions: a systematic review. Allergy. Accepted Author Manuscript., which has been published in final form at https://doi.org/10.1111/all.14258. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Accepted author manuscript, 27 MB

Cite this

Vazquez-Ortiz, M., Angier, E., Blumchen, K., Comberiati, P., Duca, B., DunnGalvin, A., Gore, C., Hox, V., Jensen, B., Pite, H., Santos, A. F., Sanchez, S., Alviani, C., Garriga-Baraut, T., Knibb, R., Mortz, C. G., Gowland, M. H., Timmermans, F., & Roberts, G. (2020). Understanding the challenges faced by adolescents and young adults with allergic conditions: a systematic review. Allergy, 75(8), 1850-1880. https://doi.org/10.1111/all.14258

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abstract = "BACKGROUND: Adolescence represents a vulnerable time for individuals with asthma and allergic conditions. They suffer an unexpected degree of morbidity. This systematic review aimed to understand the challenges faced by adolescents and young adults with these conditions.METHODS: A systematic literature search was undertaken across eight databases. References were checked by two reviewers for inclusion. Study data were extracted, and their quality was assessed in duplicate. A narrative meta-synthesis was undertaken.RESULTS: A total of 108 papers describing 106 studies were retrieved, most focused on asthma. Five themes were identified across studies: (a) Health-related quality of life-impairment was associated with poor disease control, psychosocial issues, adolescent-onset allergic disease and female sex; (b) Psychological factors-asthma and food allergy were associated with anxiety and depression, atopic dermatitis was associated with suicidal ideation, and that parental emotional support may be protective; (c) Adherence-suboptimal adherence was associated with older age, barriers to medication usage, poor symptom perception and failure to take responsibility, and positive factors were routines, simpler treatment regimes, better knowledge and perceptions about medications; (d) Self-management-facilitated by education, knowledge and a positive attitude; and (e) Supportive relationships-families could modify barriers to adherence and foster positive views about self-management, adolescents suggested that their peers should be more involved in supporting them, and adolescents also wished to have support from nonjudgemental healthcare professionals.CONCLUSIONS: We have some understanding of the challenges faced by adolescents with asthma, less so for other allergic conditions. This knowledge will be used to support guidelines for managing adolescents.",

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author = "Marta Vazquez-Ortiz and Elizabeth Angier and Katharina Blumchen and Pasquale Comberiati and Bettina Duca and Audrey DunnGalvin and Claudia Gore and Val{\'e}rie Hox and Britt Jensen and Helena Pite and Santos, \{Alexandra F\} and Silvia Sanchez and Cherry Alviani and Teresa Garriga-Baraut and Rebecca Knibb and Mortz, \{Charlotte G\} and Gowland, \{M Hazel\} and Frans Timmermans and Graham Roberts",

note = "This is the peer reviewed version of the following article: Vazquez‐Ortiz, M., Angier, E., Blumchen, K., Comberiati, P., Duca, B., DunnGalvin, A., Gore, C., Hox, V., Jensen, B., Pite, H., Santos, A.F., Sanchez, S., Alviani, C., Garriga‐Baraut, T., Knibb, R., Mortz, C.G., Gowland, M.H., Timmermans, F. and Roberts, G. (2020), Understanding the challenges faced by adolescents and young adults with allergic conditions: a systematic review. Allergy. Accepted Author Manuscript., which has been published in final form at https://doi.org/10.1111/all.14258. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving. ",

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doi = "10.1111/all.14258",

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Vazquez-Ortiz, M, Angier, E, Blumchen, K, Comberiati, P, Duca, B, DunnGalvin, A, Gore, C, Hox, V, Jensen, B, Pite, H, Santos, AF, Sanchez, S, Alviani, C, Garriga-Baraut, T, Knibb, R, Mortz, CG, Gowland, MH, Timmermans, F & Roberts, G 2020, 'Understanding the challenges faced by adolescents and young adults with allergic conditions: a systematic review', Allergy, vol. 75, no. 8, pp. 1850-1880. https://doi.org/10.1111/all.14258

TY - JOUR

T1 - Understanding the challenges faced by adolescents and young adults with allergic conditions

T2 - a systematic review

AU - Vazquez-Ortiz, Marta

AU - Angier, Elizabeth

AU - Blumchen, Katharina

AU - Comberiati, Pasquale

AU - Duca, Bettina

AU - DunnGalvin, Audrey

AU - Gore, Claudia

AU - Hox, Valérie

AU - Jensen, Britt

AU - Pite, Helena

AU - Santos, Alexandra F

AU - Sanchez, Silvia

AU - Alviani, Cherry

AU - Garriga-Baraut, Teresa

AU - Knibb, Rebecca

AU - Mortz, Charlotte G

AU - Gowland, M Hazel

AU - Timmermans, Frans

AU - Roberts, Graham

N1 - This is the peer reviewed version of the following article: Vazquez‐Ortiz, M., Angier, E., Blumchen, K., Comberiati, P., Duca, B., DunnGalvin, A., Gore, C., Hox, V., Jensen, B., Pite, H., Santos, A.F., Sanchez, S., Alviani, C., Garriga‐Baraut, T., Knibb, R., Mortz, C.G., Gowland, M.H., Timmermans, F. and Roberts, G. (2020), Understanding the challenges faced by adolescents and young adults with allergic conditions: a systematic review. Allergy. Accepted Author Manuscript., which has been published in final form at https://doi.org/10.1111/all.14258. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.

PY - 2020/8/1

Y1 - 2020/8/1

N2 - BACKGROUND: Adolescence represents a vulnerable time for individuals with asthma and allergic conditions. They suffer an unexpected degree of morbidity. This systematic review aimed to understand the challenges faced by adolescents and young adults with these conditions.METHODS: A systematic literature search was undertaken across eight databases. References were checked by two reviewers for inclusion. Study data were extracted, and their quality was assessed in duplicate. A narrative meta-synthesis was undertaken.RESULTS: A total of 108 papers describing 106 studies were retrieved, most focused on asthma. Five themes were identified across studies: (a) Health-related quality of life-impairment was associated with poor disease control, psychosocial issues, adolescent-onset allergic disease and female sex; (b) Psychological factors-asthma and food allergy were associated with anxiety and depression, atopic dermatitis was associated with suicidal ideation, and that parental emotional support may be protective; (c) Adherence-suboptimal adherence was associated with older age, barriers to medication usage, poor symptom perception and failure to take responsibility, and positive factors were routines, simpler treatment regimes, better knowledge and perceptions about medications; (d) Self-management-facilitated by education, knowledge and a positive attitude; and (e) Supportive relationships-families could modify barriers to adherence and foster positive views about self-management, adolescents suggested that their peers should be more involved in supporting them, and adolescents also wished to have support from nonjudgemental healthcare professionals.CONCLUSIONS: We have some understanding of the challenges faced by adolescents with asthma, less so for other allergic conditions. This knowledge will be used to support guidelines for managing adolescents.

AB - BACKGROUND: Adolescence represents a vulnerable time for individuals with asthma and allergic conditions. They suffer an unexpected degree of morbidity. This systematic review aimed to understand the challenges faced by adolescents and young adults with these conditions.METHODS: A systematic literature search was undertaken across eight databases. References were checked by two reviewers for inclusion. Study data were extracted, and their quality was assessed in duplicate. A narrative meta-synthesis was undertaken.RESULTS: A total of 108 papers describing 106 studies were retrieved, most focused on asthma. Five themes were identified across studies: (a) Health-related quality of life-impairment was associated with poor disease control, psychosocial issues, adolescent-onset allergic disease and female sex; (b) Psychological factors-asthma and food allergy were associated with anxiety and depression, atopic dermatitis was associated with suicidal ideation, and that parental emotional support may be protective; (c) Adherence-suboptimal adherence was associated with older age, barriers to medication usage, poor symptom perception and failure to take responsibility, and positive factors were routines, simpler treatment regimes, better knowledge and perceptions about medications; (d) Self-management-facilitated by education, knowledge and a positive attitude; and (e) Supportive relationships-families could modify barriers to adherence and foster positive views about self-management, adolescents suggested that their peers should be more involved in supporting them, and adolescents also wished to have support from nonjudgemental healthcare professionals.CONCLUSIONS: We have some understanding of the challenges faced by adolescents with asthma, less so for other allergic conditions. This knowledge will be used to support guidelines for managing adolescents.

KW - adolescent

KW - allergy

KW - asthma

KW - food allergy

KW - rhinoconjunctivitis

KW - transition

KW - young adult

UR - https://onlinelibrary.wiley.com/doi/abs/10.1111/all.14258

UR - https://www.scopus.com/pages/publications/85085686259

U2 - 10.1111/all.14258

DO - 10.1111/all.14258

M3 - Review article

C2 - 32141620

SN - 0105-4538

VL - 75

SP - 1850

EP - 1880

JO - Allergy

JF - Allergy

IS - 8

ER -

Understanding the challenges faced by adolescents and young adults with allergic conditions: a systematic review

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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Cite this