Unveiling the Catalytic Mechanism of a Processive Metalloaminopeptidase

Keyphrases

• Unveiling 100%
• Catalytic Mechanism 100%
• Processive 100%
• Metal Activation 100%
• Metallopeptidase 100%
• Steady State 66%
• Peptide Substrate 66%
• Metal Binding 66%
• Leucine Aminopeptidase 66%
• PepA 66%
• High Concentration 33%
• Metal Ions 33%
• Terminal Residue 33%
• Small Molecules 33%
• Pseudomonas Aeruginosa (P. aeruginosa) 33%
• Metal Concentration 33%
• Leucine 33%
• Tight 33%
• Specific Information 33%
• Protease 33%
• Enzyme Activity 33%
• Peptide Molecules 33%
• Quality Control 33%
• Mechanistic Studies 33%
• Peptidase 33%
• Enzyme Catalysis 33%
• Activation Mechanism 33%
• Biophysical Techniques 33%
• Substrate Preference 33%
• Hexamer 33%
• Protein Substrate 33%
• Protein Homeostasis 33%
• Protein Quality 33%
• Metalloenzymes 33%
• Chemical Mechanism 33%
• Activity Regulation 33%
• Steady-state Kinetics 33%
• Homeostasis Regulation 33%
• Catalytic Turnover 33%
• Processivity 33%
• Substrate Mimetics 33%
• Metalloprotease 33%
• Substrate Selection 33%
• PH-rate Profile 33%
• Cleavage Assay 33%
• Weak Affinity 33%
• Metal Substrate 33%
• Peptide Hydrolysis 33%
• Solvent Kinetic Isotope Effect 33%
• Assembly Control 33%
• Progress Curve 33%
• Tight Packing 33%
• Peptide Bond Cleavage 33%
• Substrate Promiscuity 33%

Biochemistry, Genetics and Molecular Biology

• Steady State 100%
• Catalytic Mechanism 100%
• Metal Binding 66%
• Leucyl Aminopeptidase 66%
• Enzyme 33%
• N-Terminus 33%
• Small Molecule 33%
• Pseudomonas aeruginosa 33%
• Crystal Structure 33%
• Enzymatic Hydrolysis 33%
• Leucine 33%
• Protease 33%
• Enzyme Activity 33%
• Peptide Bond 33%
• Peptidase 33%
• Enzyme Catalysis 33%
• Quality Control 33%
• Protein Homeostasis 33%
• Processivity 33%
• Metalloenzyme 33%
• Kinetic Isotope Effect 33%