Vagus nerve stimulation induces concomitant respiratory alterations and a decrease in SaO2 in children

Boubker Zaaimi*, Claire Héberlé, Patrick Berquin, Mickael Pruvost, Reinhard Grebe, Fabrice Wallois

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Purpose: To analyze respiratory alterations and effects on SaO2 caused by vagus nerve stimulation (VNS) in children with epilepsy. Methods: Polysomnographic recordings, including electroencephalography, thoracoabdominal distention, nasal airflow, SaO2, and VNS artifact were evaluated in 10 children with pharmacoresistant epilepsy treated with VNS. Results: Each VNS caused a significant increase in respiratory frequency (p < 0.05) throughout the stimulation period and a decrease in thoracoabdominal-distention amplitude (p < 0.05), especially at the beginning of the stimulation. These respiratory alterations induced a decrease in SaO2 from 1 to 5%. The effects of VNS on respiration differed significantly between rapid-eye-movement (REM) and non-REM (NREM) sleep states. Conclusions: VNS caused a pronounced change in respiration in children with epilepsy, and this induced a decrease in SaO 2. It is possible that VNS has a neuroprotective effect, and this possibility calls for further investigation.

Original languageEnglish
Pages (from-to)1802-1809
Number of pages8
Issue number11
Publication statusPublished - 1 Nov 2005


  • Epilepsy
  • Neuroprotection
  • Respiration
  • SaO
  • Vagus nerve stimulation

Fingerprint Dive into the research topics of 'Vagus nerve stimulation induces concomitant respiratory alterations and a decrease in SaO<sub>2</sub> in children'. Together they form a unique fingerprint.

Cite this