TY - JOUR
T1 - Vagus nerve stimulation induces concomitant respiratory alterations and a decrease in SaO2 in children
AU - Zaaimi, Boubker
AU - Héberlé, Claire
AU - Berquin, Patrick
AU - Pruvost, Mickael
AU - Grebe, Reinhard
AU - Wallois, Fabrice
PY - 2005/11/1
Y1 - 2005/11/1
N2 - Purpose: To analyze respiratory alterations and effects on SaO2 caused by vagus nerve stimulation (VNS) in children with epilepsy. Methods: Polysomnographic recordings, including electroencephalography, thoracoabdominal distention, nasal airflow, SaO2, and VNS artifact were evaluated in 10 children with pharmacoresistant epilepsy treated with VNS. Results: Each VNS caused a significant increase in respiratory frequency (p < 0.05) throughout the stimulation period and a decrease in thoracoabdominal-distention amplitude (p < 0.05), especially at the beginning of the stimulation. These respiratory alterations induced a decrease in SaO2 from 1 to 5%. The effects of VNS on respiration differed significantly between rapid-eye-movement (REM) and non-REM (NREM) sleep states. Conclusions: VNS caused a pronounced change in respiration in children with epilepsy, and this induced a decrease in SaO 2. It is possible that VNS has a neuroprotective effect, and this possibility calls for further investigation.
AB - Purpose: To analyze respiratory alterations and effects on SaO2 caused by vagus nerve stimulation (VNS) in children with epilepsy. Methods: Polysomnographic recordings, including electroencephalography, thoracoabdominal distention, nasal airflow, SaO2, and VNS artifact were evaluated in 10 children with pharmacoresistant epilepsy treated with VNS. Results: Each VNS caused a significant increase in respiratory frequency (p < 0.05) throughout the stimulation period and a decrease in thoracoabdominal-distention amplitude (p < 0.05), especially at the beginning of the stimulation. These respiratory alterations induced a decrease in SaO2 from 1 to 5%. The effects of VNS on respiration differed significantly between rapid-eye-movement (REM) and non-REM (NREM) sleep states. Conclusions: VNS caused a pronounced change in respiration in children with epilepsy, and this induced a decrease in SaO 2. It is possible that VNS has a neuroprotective effect, and this possibility calls for further investigation.
KW - Epilepsy
KW - Neuroprotection
KW - Respiration
KW - SaO
KW - Vagus nerve stimulation
UR - http://www.scopus.com/inward/record.url?scp=33644621365&partnerID=8YFLogxK
UR - https://onlinelibrary.wiley.com/doi/full/10.1111/j.1528-1167.2005.00283.x
U2 - 10.1111/j.1528-1167.2005.00283.x
DO - 10.1111/j.1528-1167.2005.00283.x
M3 - Article
C2 - 16302861
AN - SCOPUS:33644621365
SN - 0013-9580
VL - 46
SP - 1802
EP - 1809
JO - Epilepsia
JF - Epilepsia
IS - 11
ER -