Vertical optokinetic nystagmus in Parkinson's disease

Christopher M. Knapp; Irene Gottlob; Rebecca J. McLean; Yusuf A. Rajabally; Richard J. Abbott; Suzanne Rafelt; Frank A. Proudlock

doi:10.1002/mds.22634

Vertical optokinetic nystagmus in Parkinson's disease

Christopher M. Knapp, Irene Gottlob, Rebecca J. McLean, Yusuf A. Rajabally, Richard J. Abbott, Suzanne Rafelt, Frank A. Proudlock

College of Health and Life Sciences

Research output: Contribution to journal › Article › peer-review

5 Citations (SciVal)

Abstract

Parkinson's disease (PD) is associated with a number of oculomotor deficits; however, little is known about changes in vertical optokinetic nystagmus (OKN) associated with PD. We recorded eye movements in 14 PD patients and 14 age-matched controls in response to large field OKN stimulation using stimulus velocities of 20°/second and 40°/ second. We compared asymmetry of horizontal and vertical responses in the two groups. We found vertical OKN to be strongly asymmetric in PD with reduced gains for downward-moving stimuli. This asymmetry was significantly greater than that recorded in control volunteers. We postulate that this could result from an abnormal pursuit/early OKN system in PD leading to greater influence of the delayed OKN system.

Original language	English
Pages (from-to)	1533-1538
Number of pages	6
Journal	Movement Disorders
Volume	24
Issue number	10
DOIs	https://doi.org/10.1002/mds.22634
Publication status	Published - 30 Jul 2009

Keywords

Asymmetry
Dopamine
Eye movements
Optokinetic nystagmus
Parkinson's disease

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10.1002/mds.22634

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title = "Vertical optokinetic nystagmus in Parkinson's disease",

abstract = "Parkinson's disease (PD) is associated with a number of oculomotor deficits; however, little is known about changes in vertical optokinetic nystagmus (OKN) associated with PD. We recorded eye movements in 14 PD patients and 14 age-matched controls in response to large field OKN stimulation using stimulus velocities of 20°/second and 40°/ second. We compared asymmetry of horizontal and vertical responses in the two groups. We found vertical OKN to be strongly asymmetric in PD with reduced gains for downward-moving stimuli. This asymmetry was significantly greater than that recorded in control volunteers. We postulate that this could result from an abnormal pursuit/early OKN system in PD leading to greater influence of the delayed OKN system.",

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AU - Knapp, Christopher M.

AU - Gottlob, Irene

AU - McLean, Rebecca J.

AU - Rajabally, Yusuf A.

AU - Abbott, Richard J.

AU - Rafelt, Suzanne

AU - Proudlock, Frank A.

PY - 2009/7/30

Y1 - 2009/7/30

N2 - Parkinson's disease (PD) is associated with a number of oculomotor deficits; however, little is known about changes in vertical optokinetic nystagmus (OKN) associated with PD. We recorded eye movements in 14 PD patients and 14 age-matched controls in response to large field OKN stimulation using stimulus velocities of 20°/second and 40°/ second. We compared asymmetry of horizontal and vertical responses in the two groups. We found vertical OKN to be strongly asymmetric in PD with reduced gains for downward-moving stimuli. This asymmetry was significantly greater than that recorded in control volunteers. We postulate that this could result from an abnormal pursuit/early OKN system in PD leading to greater influence of the delayed OKN system.

AB - Parkinson's disease (PD) is associated with a number of oculomotor deficits; however, little is known about changes in vertical optokinetic nystagmus (OKN) associated with PD. We recorded eye movements in 14 PD patients and 14 age-matched controls in response to large field OKN stimulation using stimulus velocities of 20°/second and 40°/ second. We compared asymmetry of horizontal and vertical responses in the two groups. We found vertical OKN to be strongly asymmetric in PD with reduced gains for downward-moving stimuli. This asymmetry was significantly greater than that recorded in control volunteers. We postulate that this could result from an abnormal pursuit/early OKN system in PD leading to greater influence of the delayed OKN system.

KW - Asymmetry

KW - Dopamine

KW - Eye movements

KW - Optokinetic nystagmus

KW - Parkinson's disease

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Vertical optokinetic nystagmus in Parkinson's disease

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Keywords

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