Visual field defects in Alzheimer's disease patients may reflect differential pathology in the primary visual cortex

Richard A. Armstrong

Research output: Contribution to journalArticle

Abstract

The aim of this study was to test the hypothesis that differences in density of senile plaques (SP) and neurofibrillary tangles (NFT) in the cuneal and lingual gyri of area V1 of the visual cortex could explain the predominantly inferior visual field defects seen in patients with Alzheimer's disease (AD). The density of SP and NFT was measured in the cuneal and lingual gyri of 18 AD patients. In 7/18 (39%) patients, the density of SP and/or NFT was significantly greater in the cuneal compared with the lingual gyri. In 3/18 (17%) patients, densities were greater in the lingual than the cuneal gyri and in 8/18 (44%) patients there were no significant differences among gyri. The data suggest that pathological differences between cuneal and lingual gyri could contribute to the reported visual field defects in some AD patients.
Original languageEnglish
Pages (from-to)677-682
Number of pages6
JournalOptometry and Vision Science
Volume73
Issue number11
Publication statusPublished - Nov 1996

Keywords

  • Alzheimer's desease
  • visula field
  • area V1
  • cuneal gyri
  • lingual gyri
  • senile plaques
  • neurofibrillary tangles

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