Visual hallucinations in the psychosis spectrum and comparative information from neurodegenerative disorders and eye disease

Flavie Waters*, Daniel Collerton, Dominic H. Ffytche, Renaud Jardri, Delphine Pins, Robert Dudley, Jan Dirk Blom, Urs Peter Mosimann, Frank Eperjesi, Stephen Ford, Frank Larøi

*Corresponding author for this work

Research output: Contribution to journalSpecial issue

Abstract

Much of the research on visual hallucinations (VHs) has been conducted in the context of eye disease and neurodegenerative conditions, but little is known about these phenomena in psychiatric and nonclinical populations. The purpose of this article is to bring together current knowledge regarding VHs in the psychosis phenotype and contrast this data with the literature drawn from neurodegenerative disorders and eye disease. The evidence challenges the traditional views that VHs are atypical or uncommon in psychosis. The weighted mean for VHs is 27% in schizophrenia, 15% in affective psychosis, and 7.3% in the general community. VHs are linked to a more severe psychopathological profile and less favorable outcome in psychosis and neurodegenerative conditions. VHs typically co-occur with auditory hallucinations, suggesting a common etiological cause. VHs in psychosis are also remarkably complex, negative in content, and are interpreted to have personal relevance. The cognitive mechanisms of VHs in psychosis have rarely been investigated, but existing studies point to source-monitoring deficits and distortions in top-down mechanisms, although evidence for visual processing deficits, which feature strongly in the organic literature, is lacking. Brain imaging studies point to the activation of visual cortex during hallucinations on a background of structural and connectivity changes within wider brain networks. The relationship between VHs in psychosis, eye disease, and neurodegeneration remains unclear, although the pattern of similarities and differences described in this review suggests that comparative studies may have potentially important clinical and theoretical implications. © 2014 The Author.

Original languageEnglish
Pages (from-to)S233-S245
Number of pages13
JournalSchizophrenia Bulletin
Volume40
Issue numberSuppl.4
DOIs
Publication statusPublished - Jul 2014

Fingerprint

Eye Diseases
Hallucinations
Neurodegenerative Diseases
Psychotic Disorders
Psychotic Affective Disorders
Visual Cortex
Neuroimaging
Psychiatry
Schizophrenia
Phenotype

Bibliographical note

© The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.
This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Schizophrenia bulletin following peer review. The definitive publisher-authenticated version Waters, F., Collerton, D., Ffytche, D. H., Jardri, R., Pins, D., Dudley, R., Blom, J. D., Mosimann, U. P., Eperjesi, F., Ford, S., & Larøi, F. (2014). Visual hallucinations in the psychosis spectrum and comparative information from neurodegenerative disorders and eye disease. Schizophrenia bulletin, 40(Suppl.4), S233-S245. is available online at: http://schizophreniabulletin.oxfordjournals.org/content/40/Suppl_4/S233

Keywords

  • cognition
  • imaging
  • psychosis
  • schizophrenia
  • visual hallucinations

Cite this

Waters, F., Collerton, D., Ffytche, D. H., Jardri, R., Pins, D., Dudley, R., ... Larøi, F. (2014). Visual hallucinations in the psychosis spectrum and comparative information from neurodegenerative disorders and eye disease. Schizophrenia Bulletin, 40(Suppl.4), S233-S245. https://doi.org/10.1093/schbul/sbu036
Waters, Flavie ; Collerton, Daniel ; Ffytche, Dominic H. ; Jardri, Renaud ; Pins, Delphine ; Dudley, Robert ; Blom, Jan Dirk ; Mosimann, Urs Peter ; Eperjesi, Frank ; Ford, Stephen ; Larøi, Frank. / Visual hallucinations in the psychosis spectrum and comparative information from neurodegenerative disorders and eye disease. In: Schizophrenia Bulletin. 2014 ; Vol. 40, No. Suppl.4. pp. S233-S245.
@article{82231c33ac784cb9a3e4c0f5c873ef86,
title = "Visual hallucinations in the psychosis spectrum and comparative information from neurodegenerative disorders and eye disease",
abstract = "Much of the research on visual hallucinations (VHs) has been conducted in the context of eye disease and neurodegenerative conditions, but little is known about these phenomena in psychiatric and nonclinical populations. The purpose of this article is to bring together current knowledge regarding VHs in the psychosis phenotype and contrast this data with the literature drawn from neurodegenerative disorders and eye disease. The evidence challenges the traditional views that VHs are atypical or uncommon in psychosis. The weighted mean for VHs is 27{\%} in schizophrenia, 15{\%} in affective psychosis, and 7.3{\%} in the general community. VHs are linked to a more severe psychopathological profile and less favorable outcome in psychosis and neurodegenerative conditions. VHs typically co-occur with auditory hallucinations, suggesting a common etiological cause. VHs in psychosis are also remarkably complex, negative in content, and are interpreted to have personal relevance. The cognitive mechanisms of VHs in psychosis have rarely been investigated, but existing studies point to source-monitoring deficits and distortions in top-down mechanisms, although evidence for visual processing deficits, which feature strongly in the organic literature, is lacking. Brain imaging studies point to the activation of visual cortex during hallucinations on a background of structural and connectivity changes within wider brain networks. The relationship between VHs in psychosis, eye disease, and neurodegeneration remains unclear, although the pattern of similarities and differences described in this review suggests that comparative studies may have potentially important clinical and theoretical implications. {\circledC} 2014 The Author.",
keywords = "cognition, imaging, psychosis, schizophrenia, visual hallucinations",
author = "Flavie Waters and Daniel Collerton and Ffytche, {Dominic H.} and Renaud Jardri and Delphine Pins and Robert Dudley and Blom, {Jan Dirk} and Mosimann, {Urs Peter} and Frank Eperjesi and Stephen Ford and Frank Lar{\o}i",
note = "{\circledC} The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Schizophrenia bulletin following peer review. The definitive publisher-authenticated version Waters, F., Collerton, D., Ffytche, D. H., Jardri, R., Pins, D., Dudley, R., Blom, J. D., Mosimann, U. P., Eperjesi, F., Ford, S., & Lar{\o}i, F. (2014). Visual hallucinations in the psychosis spectrum and comparative information from neurodegenerative disorders and eye disease. Schizophrenia bulletin, 40(Suppl.4), S233-S245. is available online at: http://schizophreniabulletin.oxfordjournals.org/content/40/Suppl_4/S233",
year = "2014",
month = "7",
doi = "10.1093/schbul/sbu036",
language = "English",
volume = "40",
pages = "S233--S245",
journal = "Schizophrenia Bulletin",
issn = "0586-7614",
publisher = "Oxford University Press",
number = "Suppl.4",

}

Waters, F, Collerton, D, Ffytche, DH, Jardri, R, Pins, D, Dudley, R, Blom, JD, Mosimann, UP, Eperjesi, F, Ford, S & Larøi, F 2014, 'Visual hallucinations in the psychosis spectrum and comparative information from neurodegenerative disorders and eye disease', Schizophrenia Bulletin, vol. 40, no. Suppl.4, pp. S233-S245. https://doi.org/10.1093/schbul/sbu036

Visual hallucinations in the psychosis spectrum and comparative information from neurodegenerative disorders and eye disease. / Waters, Flavie; Collerton, Daniel; Ffytche, Dominic H.; Jardri, Renaud; Pins, Delphine; Dudley, Robert; Blom, Jan Dirk; Mosimann, Urs Peter; Eperjesi, Frank; Ford, Stephen; Larøi, Frank.

In: Schizophrenia Bulletin, Vol. 40, No. Suppl.4, 07.2014, p. S233-S245.

Research output: Contribution to journalSpecial issue

TY - JOUR

T1 - Visual hallucinations in the psychosis spectrum and comparative information from neurodegenerative disorders and eye disease

AU - Waters, Flavie

AU - Collerton, Daniel

AU - Ffytche, Dominic H.

AU - Jardri, Renaud

AU - Pins, Delphine

AU - Dudley, Robert

AU - Blom, Jan Dirk

AU - Mosimann, Urs Peter

AU - Eperjesi, Frank

AU - Ford, Stephen

AU - Larøi, Frank

N1 - © The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Schizophrenia bulletin following peer review. The definitive publisher-authenticated version Waters, F., Collerton, D., Ffytche, D. H., Jardri, R., Pins, D., Dudley, R., Blom, J. D., Mosimann, U. P., Eperjesi, F., Ford, S., & Larøi, F. (2014). Visual hallucinations in the psychosis spectrum and comparative information from neurodegenerative disorders and eye disease. Schizophrenia bulletin, 40(Suppl.4), S233-S245. is available online at: http://schizophreniabulletin.oxfordjournals.org/content/40/Suppl_4/S233

PY - 2014/7

Y1 - 2014/7

N2 - Much of the research on visual hallucinations (VHs) has been conducted in the context of eye disease and neurodegenerative conditions, but little is known about these phenomena in psychiatric and nonclinical populations. The purpose of this article is to bring together current knowledge regarding VHs in the psychosis phenotype and contrast this data with the literature drawn from neurodegenerative disorders and eye disease. The evidence challenges the traditional views that VHs are atypical or uncommon in psychosis. The weighted mean for VHs is 27% in schizophrenia, 15% in affective psychosis, and 7.3% in the general community. VHs are linked to a more severe psychopathological profile and less favorable outcome in psychosis and neurodegenerative conditions. VHs typically co-occur with auditory hallucinations, suggesting a common etiological cause. VHs in psychosis are also remarkably complex, negative in content, and are interpreted to have personal relevance. The cognitive mechanisms of VHs in psychosis have rarely been investigated, but existing studies point to source-monitoring deficits and distortions in top-down mechanisms, although evidence for visual processing deficits, which feature strongly in the organic literature, is lacking. Brain imaging studies point to the activation of visual cortex during hallucinations on a background of structural and connectivity changes within wider brain networks. The relationship between VHs in psychosis, eye disease, and neurodegeneration remains unclear, although the pattern of similarities and differences described in this review suggests that comparative studies may have potentially important clinical and theoretical implications. © 2014 The Author.

AB - Much of the research on visual hallucinations (VHs) has been conducted in the context of eye disease and neurodegenerative conditions, but little is known about these phenomena in psychiatric and nonclinical populations. The purpose of this article is to bring together current knowledge regarding VHs in the psychosis phenotype and contrast this data with the literature drawn from neurodegenerative disorders and eye disease. The evidence challenges the traditional views that VHs are atypical or uncommon in psychosis. The weighted mean for VHs is 27% in schizophrenia, 15% in affective psychosis, and 7.3% in the general community. VHs are linked to a more severe psychopathological profile and less favorable outcome in psychosis and neurodegenerative conditions. VHs typically co-occur with auditory hallucinations, suggesting a common etiological cause. VHs in psychosis are also remarkably complex, negative in content, and are interpreted to have personal relevance. The cognitive mechanisms of VHs in psychosis have rarely been investigated, but existing studies point to source-monitoring deficits and distortions in top-down mechanisms, although evidence for visual processing deficits, which feature strongly in the organic literature, is lacking. Brain imaging studies point to the activation of visual cortex during hallucinations on a background of structural and connectivity changes within wider brain networks. The relationship between VHs in psychosis, eye disease, and neurodegeneration remains unclear, although the pattern of similarities and differences described in this review suggests that comparative studies may have potentially important clinical and theoretical implications. © 2014 The Author.

KW - cognition

KW - imaging

KW - psychosis

KW - schizophrenia

KW - visual hallucinations

UR - http://www.scopus.com/inward/record.url?scp=84902587275&partnerID=8YFLogxK

U2 - 10.1093/schbul/sbu036

DO - 10.1093/schbul/sbu036

M3 - Special issue

C2 - 24936084

VL - 40

SP - S233-S245

JO - Schizophrenia Bulletin

JF - Schizophrenia Bulletin

SN - 0586-7614

IS - Suppl.4

ER -