Visual signs and symptoms of corticobasal degeneration

Richard A. Armstrong

Research output: Contribution to journalReview article

Abstract

Corticobasal degeneration is a rare, progressive neurodegenerative disease and a member of the 'parkinsonian' group of disorders, which also includes Parkinson's disease, progressive supranuclear palsy, dementia with Lewy bodies and multiple system atrophy. The most common initial symptom is limb clumsiness, usually affecting one side of the body, with or without accompanying rigidity or tremor. Subsequently, the disease affects gait and there is a slow progression to influence ipsilateral arms and legs. Apraxia and dementia are the most common cortical signs. Corticobasal degeneration can be difficult to distinguish from other parkinsonian syndromes but if ocular signs and symptoms are present, they may aid clinical diagnosis. Typical ocular features include increased latency of saccadic eye movements ipsilateral to the side exhibiting apraxia, impaired smooth pursuit movements and visuo-spatial dysfunction, especially involving spatial rather than object-based tasks. Less typical features include reduction in saccadic velocity, vertical gaze palsy, visual hallucinations, sleep disturbance and an impaired electroretinogram. Aspects of primary vision such as visual acuity and colour vision are usually unaffected. Management of the condition to deal with problems of walking, movement, daily tasks and speech problems is an important aspect of the disease.

LanguageEnglish
Pages498-506
JournalClinical and Experimental Optometry
Volume99
Issue number6
Early online date23 Aug 2016
DOIs
Publication statusE-pub ahead of print - 23 Aug 2016

Fingerprint

Apraxias
Parkinsonian Disorders
Signs and Symptoms
Smooth Pursuit
Progressive Supranuclear Palsy
Multiple System Atrophy
Lewy Body Disease
Color Vision
Saccades
Hallucinations
Tremor
Gait
Paralysis
Neurodegenerative Diseases
Visual Acuity
Walking
Parkinson Disease
Dementia
Leg
Sleep

Bibliographical note

This is the peer reviewed version of the following article: Armstrong, RA 2016, 'Visual signs and symptoms of corticobasal degeneration' Clinical and Experimental Optometry, vol. Early view, which has been published in final form at http://dx.doi.org/10.1111/cxo.12429. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

Keywords

  • Parkinsonian syndrome
  • saccadic eye movement
  • tauopathy
  • visuo-spatial function

Cite this

Armstrong, Richard A. / Visual signs and symptoms of corticobasal degeneration. In: Clinical and Experimental Optometry. 2016 ; Vol. 99, No. 6. pp. 498-506.
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Visual signs and symptoms of corticobasal degeneration. / Armstrong, Richard A.

In: Clinical and Experimental Optometry, Vol. 99, No. 6, 23.08.2016, p. 498-506.

Research output: Contribution to journalReview article

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