Wearable laser Doppler flowmetry for the analysis of microcirculatory changes during intravenous infusion in patients with diabetes mellitus

Elena V. Zharkikh; Yulia I. Loktionova; Igor O. Kozlov; Angelina I. Zherebtsova; Victor V. Sidorov; Evgeny A. Zherebtsov; Andrey V. Dunaev; Edik U. Rafailov

doi:10.1117/12.2552464

Wearable laser Doppler flowmetry for the analysis of microcirculatory changes during intravenous infusion in patients with diabetes mellitus

Elena V. Zharkikh^*, Yulia I. Loktionova, Igor O. Kozlov, Angelina I. Zherebtsova, Victor V. Sidorov, Evgeny A. Zherebtsov, Andrey V. Dunaev, Edik U. Rafailov

^*Corresponding author for this work

Aston Institute of Photonic Technologies (AiPT)

Research output: Contribution to journal › Conference article › peer-review

Abstract

The article is aimed at conducting pilot studies of microcirculation changes in patients with diabetes mellitus during the course of intravenous infusions of alpha lipoic acid. The study was conducted with patients with diabetes during the passage of a standard course of treatment. The change in parameters was compared before the start of the infusion course, during and after the course. A system of wearable laser Doppler monitors was used to conduct the study. The study showed that although the microcirculation index does not undergo significant changes during the treatment process, spectral analysis of the recorded signal has potential applicability. Further studies with a larger sample group are required for a qualitative analysis of the observed effects.

Original language	English
Article number	113631K
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	11363
DOIs	https://doi.org/10.1117/12.2552464
Publication status	Published - 2 Apr 2020
Event	Tissue Optics and Photonics 2020 - None, France Duration: 6 Apr 2020 → 10 Apr 2020

Bibliographical note

Copyright 2020 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

Funding Information:
This study was funded by the Russian Science Foundation (the research project 18-79-00237).

Keywords

Alpha lipoic acid
Diabetic neuropathy
Laser Doppler flowmetry
Skin blood flow
Wearable electronics

Access to Document

10.1117/12.2552464

113631K
Copyright 2020 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Final published version, 2.64 MB

Cite this

Zharkikh, E. V., Loktionova, Y. I., Kozlov, I. O., Zherebtsova, A. I., Sidorov, V. V., Zherebtsov, E. A., Dunaev, A. V., & Rafailov, E. U. (2020). Wearable laser Doppler flowmetry for the analysis of microcirculatory changes during intravenous infusion in patients with diabetes mellitus. Proceedings of SPIE - The International Society for Optical Engineering, 11363, Article 113631K. https://doi.org/10.1117/12.2552464

@article{498c3a9798ed4a9786b7eb599399750f,

title = "Wearable laser Doppler flowmetry for the analysis of microcirculatory changes during intravenous infusion in patients with diabetes mellitus",

abstract = "The article is aimed at conducting pilot studies of microcirculation changes in patients with diabetes mellitus during the course of intravenous infusions of alpha lipoic acid. The study was conducted with patients with diabetes during the passage of a standard course of treatment. The change in parameters was compared before the start of the infusion course, during and after the course. A system of wearable laser Doppler monitors was used to conduct the study. The study showed that although the microcirculation index does not undergo significant changes during the treatment process, spectral analysis of the recorded signal has potential applicability. Further studies with a larger sample group are required for a qualitative analysis of the observed effects.",

keywords = "Alpha lipoic acid, Diabetic neuropathy, Laser Doppler flowmetry, Skin blood flow, Wearable electronics",

author = "Zharkikh, {Elena V.} and Loktionova, {Yulia I.} and Kozlov, {Igor O.} and Zherebtsova, {Angelina I.} and Sidorov, {Victor V.} and Zherebtsov, {Evgeny A.} and Dunaev, {Andrey V.} and Rafailov, {Edik U.}",

note = "Copyright 2020 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. Funding Information: This study was funded by the Russian Science Foundation (the research project 18-79-00237).; Tissue Optics and Photonics 2020 ; Conference date: 06-04-2020 Through 10-04-2020",

year = "2020",

month = apr,

day = "2",

doi = "10.1117/12.2552464",

language = "English",

volume = "11363",

journal = "Proceedings of SPIE - The International Society for Optical Engineering",

issn = "0277-786X",

publisher = "SPIE",

}

Zharkikh, EV, Loktionova, YI, Kozlov, IO, Zherebtsova, AI, Sidorov, VV, Zherebtsov, EA, Dunaev, AV & Rafailov, EU 2020, 'Wearable laser Doppler flowmetry for the analysis of microcirculatory changes during intravenous infusion in patients with diabetes mellitus', Proceedings of SPIE - The International Society for Optical Engineering, vol. 11363, 113631K. https://doi.org/10.1117/12.2552464

Wearable laser Doppler flowmetry for the analysis of microcirculatory changes during intravenous infusion in patients with diabetes mellitus. / Zharkikh, Elena V.; Loktionova, Yulia I.; Kozlov, Igor O. et al.
In: Proceedings of SPIE - The International Society for Optical Engineering, Vol. 11363, 113631K, 02.04.2020.

Research output: Contribution to journal › Conference article › peer-review

TY - JOUR

T1 - Wearable laser Doppler flowmetry for the analysis of microcirculatory changes during intravenous infusion in patients with diabetes mellitus

AU - Zharkikh, Elena V.

AU - Loktionova, Yulia I.

AU - Kozlov, Igor O.

AU - Zherebtsova, Angelina I.

AU - Sidorov, Victor V.

AU - Zherebtsov, Evgeny A.

AU - Dunaev, Andrey V.

AU - Rafailov, Edik U.

N1 - Copyright 2020 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. Funding Information: This study was funded by the Russian Science Foundation (the research project 18-79-00237).

PY - 2020/4/2

Y1 - 2020/4/2

N2 - The article is aimed at conducting pilot studies of microcirculation changes in patients with diabetes mellitus during the course of intravenous infusions of alpha lipoic acid. The study was conducted with patients with diabetes during the passage of a standard course of treatment. The change in parameters was compared before the start of the infusion course, during and after the course. A system of wearable laser Doppler monitors was used to conduct the study. The study showed that although the microcirculation index does not undergo significant changes during the treatment process, spectral analysis of the recorded signal has potential applicability. Further studies with a larger sample group are required for a qualitative analysis of the observed effects.

AB - The article is aimed at conducting pilot studies of microcirculation changes in patients with diabetes mellitus during the course of intravenous infusions of alpha lipoic acid. The study was conducted with patients with diabetes during the passage of a standard course of treatment. The change in parameters was compared before the start of the infusion course, during and after the course. A system of wearable laser Doppler monitors was used to conduct the study. The study showed that although the microcirculation index does not undergo significant changes during the treatment process, spectral analysis of the recorded signal has potential applicability. Further studies with a larger sample group are required for a qualitative analysis of the observed effects.

KW - Alpha lipoic acid

KW - Diabetic neuropathy

KW - Laser Doppler flowmetry

KW - Skin blood flow

KW - Wearable electronics

UR - http://www.scopus.com/inward/record.url?scp=85087090879&partnerID=8YFLogxK

UR - https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11363/2552464/Wearable-laser-Doppler-flowmetry-for-the-analysis-of-microcirculatory-changes/10.1117/12.2552464.full

U2 - 10.1117/12.2552464

DO - 10.1117/12.2552464

M3 - Conference article

AN - SCOPUS:85087090879

SN - 0277-786X

VL - 11363

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

M1 - 113631K

T2 - Tissue Optics and Photonics 2020

Y2 - 6 April 2020 through 10 April 2020

ER -

Wearable laser Doppler flowmetry for the analysis of microcirculatory changes during intravenous infusion in patients with diabetes mellitus

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this