Wearable sensor system for multipoint measurements of blood perfusion: pilot studies in patients with diabetes mellitus

Evgeny A. Zherebtsov, Elena V. Zharkikh, Igor O. Kozlov, Yulia I. Loktionova, Angelina I. Zherebtsova, Ilya E. Rafailov, Sergei G. Sokolovski, Victor V. Sidorov, Andrey V. Dunaev, Edik U. Rafailov, Lothar D. Lilge (Editor), Carsten M. Philipp (Editor)

Research output: Contribution to journalConference article

Abstract

The growing interest in the development of new wearable electronic devices for mobile healthcare provides great opportunities for the development of methods for assessing blood perfusion in this direction. Laser Doppler flowmetry (LDF) is one of the promising methods. A fine analysis of capillary blood ow structure and rhythm in the time and frequency domains, coupled with a new possibility of round-the-clock monitoring can provide valuable diagnostic information about the state of microvascular blood ow. In this study, wearable implementation of laser Doppler flowmetry was utilised for microcirculatory function assessment in patients with diabetes and healthy controls of two distinct age groups. Four wearable laser Doppler flowmetry monitors were used for the analysis of blood microcirculation. Thirty-seven healthy volunteers and 18 patients with type 2 diabetes mellitus participated in the study. The results of the studies have shown that the average perfusion differs between healthy volunteers of distinct age groups and between healthy volunteers of the younger age group and patients with diabetes mellitus. It was noted that the average level of perfusion measured on the wrist in the two groups of healthy volunteers has no statistically significant differences found in similar measurements on the fingertips. The wearable implementation of LDF can become a truly new diagnostic interface to monitor cardiovascular parameters, which could be of interest for diagnostics of conditions associated with microvascular disorders.
Original languageEnglish
Article number110791O
JournalProceedings of SPIE - International Society for Optical Engineering
Volume11079
DOIs
Publication statusPublished - 22 Jul 2019
EventTranslation of Lasers and Biophotonics Technologies and Procedures: Toward the Clinic - Munich, Germany
Duration: 23 Jun 201927 Jun 2019

Bibliographical note

Copyright 2019 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

Funding: Russian Science Foundation (the research project 18-79-00237), grant of Academy of Finland No.318281

Keywords

  • Ageing
  • Blood flow
  • Diabetes mellitus
  • Laser Doppler owmetry
  • Wearable blood perfusion sensor

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    Zherebtsov, E. A., Zharkikh, E. V., Kozlov, I. O., Loktionova, Y. I., Zherebtsova, A. I., Rafailov, I. E., Sokolovski, S. G., Sidorov, V. V., Dunaev, A. V., Rafailov, E. U., Lilge, L. D. (Ed.), & Philipp, C. M. (Ed.) (2019). Wearable sensor system for multipoint measurements of blood perfusion: pilot studies in patients with diabetes mellitus. Proceedings of SPIE - International Society for Optical Engineering, 11079, [110791O]. https://doi.org/10.1117/12.2526966