Zebrafish as a model to investigate the CRH axis and interactions with DISC1

Helen Eachus; Soojin Ryu; Marysia Placzek; Jonathan Wood

doi:10.1016/j.coemr.2022.100383

Zebrafish as a model to investigate the CRH axis and interactions with DISC1

Helen Eachus
, Soojin Ryu
, Marysia Placzek
, Jonathan Wood^*

^*Corresponding author for this work

Aston Pharmacy School

Research output: Contribution to journal › Review article › peer-review

10 Citations (SciVal)

Abstract

Release of corticotropin-releasing hormone (CRH) from CRH neurons activates the hypothalamo–pituitary–adrenal (HPA) axis, one of the main physiological stress response systems. Complex feedback loops operate in the HPA axis and understanding the neurobiological mechanisms regulating CRH neurons is of great importance in the context of stress disorders. In this article, we review how in vivo studies in zebrafish have advanced knowledge of the neurobiology of CRH neurons. Disrupted-in-schizophrenia 1 (DISC1) mutant zebrafish have blunted stress responses and can be used to model human stress disorders. We propose that DISC1 influences the development and functioning of CRH neurons as a mechanism linking DISC1 to psychiatric disorders.

Original language	English
Article number	100383
Journal	Current Opinion in Endocrine and Metabolic Research
Volume	26
Early online date	29 Aug 2022
DOIs	https://doi.org/10.1016/j.coemr.2022.100383
Publication status	Published - Oct 2022

Funding

SR and HE are supported by the Mireille Gillings Foundation . SR is also supported by the German Federal Office for Education and Research grant number 01GQ1404 . HE is also supported by the Wellcome Trust Institutional Strategic Support Award ( WT105618MA ). MP is supported by the Wellcome Trust (212247/Z/18/Z).

Funders	Funder number
German Federal Office for Education and Research	01GQ1404
Mireille Gillings Foundation
Wellcome Trust	WT105618MA, 212247/Z/18/Z

Keywords

CRF
CRH
DISC1
HPA axis
HPI axis
Hypothalamus
Zebrafish

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10.1016/j.coemr.2022.100383Licence: CC BY 4.0

Cite this

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title = "Zebrafish as a model to investigate the CRH axis and interactions with DISC1",

abstract = "Release of corticotropin-releasing hormone (CRH) from CRH neurons activates the hypothalamo–pituitary–adrenal (HPA) axis, one of the main physiological stress response systems. Complex feedback loops operate in the HPA axis and understanding the neurobiological mechanisms regulating CRH neurons is of great importance in the context of stress disorders. In this article, we review how in vivo studies in zebrafish have advanced knowledge of the neurobiology of CRH neurons. Disrupted-in-schizophrenia 1 (DISC1) mutant zebrafish have blunted stress responses and can be used to model human stress disorders. We propose that DISC1 influences the development and functioning of CRH neurons as a mechanism linking DISC1 to psychiatric disorders.",

keywords = "CRF, CRH, DISC1, HPA axis, HPI axis, Hypothalamus, Zebrafish",

author = "Helen Eachus and Soojin Ryu and Marysia Placzek and Jonathan Wood",

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doi = "10.1016/j.coemr.2022.100383",

language = "English",

volume = "26",

journal = "Current Opinion in Endocrine and Metabolic Research",

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T1 - Zebrafish as a model to investigate the CRH axis and interactions with DISC1

AU - Eachus, Helen

AU - Ryu, Soojin

AU - Placzek, Marysia

AU - Wood, Jonathan

PY - 2022/10

Y1 - 2022/10

N2 - Release of corticotropin-releasing hormone (CRH) from CRH neurons activates the hypothalamo–pituitary–adrenal (HPA) axis, one of the main physiological stress response systems. Complex feedback loops operate in the HPA axis and understanding the neurobiological mechanisms regulating CRH neurons is of great importance in the context of stress disorders. In this article, we review how in vivo studies in zebrafish have advanced knowledge of the neurobiology of CRH neurons. Disrupted-in-schizophrenia 1 (DISC1) mutant zebrafish have blunted stress responses and can be used to model human stress disorders. We propose that DISC1 influences the development and functioning of CRH neurons as a mechanism linking DISC1 to psychiatric disorders.

AB - Release of corticotropin-releasing hormone (CRH) from CRH neurons activates the hypothalamo–pituitary–adrenal (HPA) axis, one of the main physiological stress response systems. Complex feedback loops operate in the HPA axis and understanding the neurobiological mechanisms regulating CRH neurons is of great importance in the context of stress disorders. In this article, we review how in vivo studies in zebrafish have advanced knowledge of the neurobiology of CRH neurons. Disrupted-in-schizophrenia 1 (DISC1) mutant zebrafish have blunted stress responses and can be used to model human stress disorders. We propose that DISC1 influences the development and functioning of CRH neurons as a mechanism linking DISC1 to psychiatric disorders.

KW - CRF

KW - CRH

KW - DISC1

KW - HPA axis

KW - HPI axis

KW - Hypothalamus

KW - Zebrafish

UR - https://www.scopus.com/pages/publications/85138505663

UR - https://www.sciencedirect.com/science/article/pii/S2451965022000680?via%3Dihub

U2 - 10.1016/j.coemr.2022.100383

DO - 10.1016/j.coemr.2022.100383

M3 - Review article

AN - SCOPUS:85138505663

SN - 2451-9650

VL - 26

JO - Current Opinion in Endocrine and Metabolic Research

JF - Current Opinion in Endocrine and Metabolic Research

M1 - 100383

ER -

Zebrafish as a model to investigate the CRH axis and interactions with DISC1

Abstract

Funding

Keywords

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