Biopterin metabolism in health and disease

  • Ayser Yousif Mustafa Al-Beir

Student thesis: Master's ThesisMaster of Philosophy

Abstract

Tetrahydrobiopterin metabolism in man has been studied in three ways. Firstly the serum concentration of biopterin derivatives was measured using a Crithidia fasiculata assay. Secondly the urine concentration of neopterin and biopterin was estimated by high performance liquid chromatography. Thirdly the urine concentration of tetrahydrobiopterin was determined by an enzymatic assay using phenylalanine hydroxylase. The results obtained have been correlated with various disease states and previous studies of tetrahydrobiopterin metabolism so as to extend our understanding of tetrahydrobiopterin metabolism...
Date of Award1982
Original languageEnglish
Awarding Institution
  • Aston University

Keywords

  • biopterin
  • neopterin
  • urine
  • serum

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