Tetrahydrobiopterin metabolism in man has been studied in three ways. Firstly the serum concentration of biopterin derivatives was measured using a Crithidia fasiculata assay. Secondly the urine concentration of neopterin and biopterin was estimated by high performance liquid chromatography. Thirdly the urine concentration of tetrahydrobiopterin was determined by an enzymatic assay using phenylalanine hydroxylase. The results obtained have been correlated with various disease states and previous studies of tetrahydrobiopterin metabolism so as to extend our understanding of tetrahydrobiopterin metabolism...
| Date of Award | 1982 |
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| Original language | English |
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| Awarding Institution | |
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- biopterin
- neopterin
- urine
- serum
Biopterin metabolism in health and disease
Al-Beir, A. Y. M. (Author). 1982
Student thesis: Master's Thesis › Master of Philosophy