AbstractThe Retinal Vessel Analyser (RVA) is a commercially available ophthalmoscopic instrument capable of acquiring vessel diameter fluctuations in real time and in high temporal resolution.
Visual stimulation by means of flickering light is a unique exploration tool of neurovascular
coupling in the human retina. Vessel reactivity as mediated by local vascular endothelial vasodilators and vasoconstrictors can be assessed non-invasively, in vivo. In brief, the work in
• deals with interobserver and intraobserver reproducibility of the flicker responses in healthy volunteers
• explains the superiority of individually analysed reactivity parameters over vendorgenerated
• links in static retinal measures with dynamic ones
• highlights practical limitations in the use of the RVA that may undermine its clinical
• provides recommendations for standardising measurements in terms of vessel location
and vessel segment length and
• presents three case reports of essential hypertensives in a -year follow-up.
Strict standardisation of measurement procedures is a necessity when utilising the RVA system.
Agreement between research groups on implemented protocols needs to be met, before it could
be considered a clinically useful tool in detecting or predicting microvascular dysfunction.
|Date of Award||12 Mar 2014|
|Supervisor||Rebekka Heitmar (Supervisor)|
- Cardiovascular Disease
- Blood Pressure
- Endothelial Function
Retinal vessel analysis: flicker reproducibility, methodological standardisations and practical limitations
Kalitzeos, A. (Author). 12 Mar 2014
Student thesis: Doctoral Thesis › Doctor of Philosophy