Structure-Activity Studies on Antitumour Imidazotetrazionones

  • Keith R. Horspool

Student thesis: Doctoral ThesisDoctor of Philosophy

Abstract

A review of the chemical and antitumour properties of imidazotetrazinones and in particular for that of mitozolomide, 8-carbamoyl-3-(2- chloroethyl)imidazo[5.1-d]-1.2.3.5-tetrazin-4(3H)-one (CMCIT) is presented. Previously proposed mechanisms of action for CMCIT are described, with special attention being given to its alkylating properties, conferred by the 3-chloroethyl substituent...
Date of Award1988
Original languageEnglish
Awarding Institution
  • Aston University

Keywords

  • Structure-activity
  • antitumour
  • imidazotetrazionones

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