A review of the chemical and antitumour properties of imidazotetrazinones and in particular for that of mitozolomide, 8-carbamoyl-3-(2- chloroethyl)imidazo[5.1-d]-1.2.3.5-tetrazin-4(3H)-one (CMCIT) is presented. Previously proposed mechanisms of action for CMCIT are described, with special attention being given to its alkylating properties, conferred by the 3-chloroethyl substituent...
| Date of Award | 1988 |
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| Original language | English |
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| Awarding Institution | |
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- Structure-activity
- antitumour
- imidazotetrazionones
Structure-Activity Studies on Antitumour Imidazotetrazionones
Horspool, K. R. (Author). 1988
Student thesis: Doctoral Thesis › Doctor of Philosophy