Studies of Folate Catabolism in the Rat

Abstract

The metabolism of a mixture of [2-¹⁴C] and [3',5',7,9-³H]-folic acid
was studied in adult male and adult female rats. Both sexes were found
to metabolise folic acid to various compounds. Intact folates and
catabolites were excreted in the urine and folate polyglutamates were found in the tissues. The extent of tissue uptake and catabolism were found to vary between the male and female rat. Female rats treated with diethylstilboestrol and mazola corn oil showed marked changes in the metabolic handling of folic acid. Less radioactivity was excreted in the urine and catabolism was greatly reduced. There was also a major shift towards 10CHO-folate in the urinary metabolites...

Date of Award	May 1984
Original language	English
Awarding Institution	Aston University