Studies on Chemical Tansmission in the Non-Sympathetic Inhibitory Nervous Pathway to the Stomach.

Abstract

Vagal stimulation of the guinea-pig or rat stomach in the presence of hyoscine (0.23µM) gave a relaxation which was resistant to guanethidine (16.9µM) but reduced by hexamethonium (55.2µM) or pempidine (I5.0µM). Relaxations were also produced in the presence of hexamethonium (20.0 to 55.2µM)
or pempidine (2.0 to I5.OµM) alone,which were also resistant to guanethidine (16.9µM). These relaxations were reduced by low concentrations of hyoscine (0.023µM).The latency of the response in the presence of ganglion blocking drugs alone was Longer than that in the presence of
hyoscine alone....

Date of Award	Sept 1980
Original language	English
Awarding Institution	Aston University